Human Gene CCDC91 (ENST00000545336.5) from GENCODE V44
  Description: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). (from UniProt Q7Z6B0)
Gencode Transcript: ENST00000545336.5
Gencode Gene: ENSG00000123106.11
Transcript (Including UTRs)
   Position: hg38 chr12:28,190,446-28,550,166 Size: 359,721 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg38 chr12:28,257,216-28,549,173 Size: 291,958 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:28,190,446-28,550,166)mRNA (may differ from genome)Protein (441 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIneXtProtPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CCD91_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 91; AltName: Full=GGA-binding partner; AltName: Full=p56 accessory protein;
FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).
SUBUNIT: Homodimer. Interacts with GGA1, GGA2 and AP1G1.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Colocalizes with GGA1 and GGA2. May be recruited to the TGN by GGA1 and GGA2.
TISSUE SPECIFICITY: Widely expressed.
SEQUENCE CAUTION: Sequence=BAA91995.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.12 RPKM in Testis
Total median expression: 256.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -149.00419-0.356 Picture PostScript Text
3' UTR -196.90993-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Protein Data Bank (PDB) 3-D Structure
MuPIT help
1OM9 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q7Z6B0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042802 identical protein binding

Biological Process:
GO:0015031 protein transport
GO:0048193 Golgi vesicle transport
GO:0090160 Golgi to lysosome transport

Cellular Component:
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK093152 - Homo sapiens cDNA FLJ35833 fis, clone TESTI2006565, highly similar to Coiled-coil domain-containing protein 91.
AX747957 - Sequence 1482 from Patent EP1308459.
AK309181 - Homo sapiens cDNA, FLJ99222.
BC018679 - Homo sapiens coiled-coil domain containing 91, mRNA (cDNA clone IMAGE:4663649), partial cds.
AY289196 - Homo sapiens p56 mRNA, complete cds.
AB587421 - Synthetic construct DNA, clone: pF1KB6636, Homo sapiens CCDC91 gene for coiled-coil domain containing 91, without stop codon, in Flexi system.
BC028682 - Homo sapiens coiled-coil domain containing 91, mRNA (cDNA clone MGC:26162 IMAGE:4827882), complete cds.
KJ902808 - Synthetic construct Homo sapiens clone ccsbBroadEn_12202 CCDC91 gene, encodes complete protein.
CR749586 - Homo sapiens mRNA; cDNA DKFZp779L1558 (from clone DKFZp779L1558).
AK001950 - Homo sapiens cDNA FLJ11088 fis, clone PLACE1005287, weakly similar to INNER CENTROMERE PROTEIN.
AY251168 - Homo sapiens HSD8 mRNA, complete cds.
CR457277 - Homo sapiens full open reading frame cDNA clone RZPDo834F029D for gene FLJ11088, GGA binding partner; complete cds, incl. stopcodon.
BC035168 - Homo sapiens cDNA clone IMAGE:5265732.
DQ576348 - Homo sapiens piRNA piR-44460, complete sequence.
JD038079 - Sequence 19103 from Patent EP1572962.
JD082261 - Sequence 63285 from Patent EP1572962.
JD501167 - Sequence 482191 from Patent EP1572962.
JD377373 - Sequence 358397 from Patent EP1572962.
JD359475 - Sequence 340499 from Patent EP1572962.
JD349831 - Sequence 330855 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KSA3, C9JR07, CCD91_HUMAN, ENST00000545336.1, ENST00000545336.2, ENST00000545336.3, ENST00000545336.4, GGABP, HSD8, NM_001387000, Q68D43, Q6IA78, Q7Z6B0, Q8NEN7, Q9NUW9, uc001riq.1, uc001riq.2, uc001riq.3, uc001riq.4
UCSC ID: ENST00000545336.5
RefSeq Accession: NM_001352078
Protein: Q7Z6B0 (aka CCD91_HUMAN)
CCDS: CCDS8716.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.