Human Gene PUS7L (ENST00000416848.6) from GENCODE V44
Description: tRNA uridine = tRNA pseudouridine. (from UniProt Q9H0K6)
Gencode Transcript: ENST00000416848.6
Gencode Gene: ENSG00000129317.15
Transcript (Including UTRs)
Position: hg38 chr12:43,728,607-43,758,758 Size: 30,152 Total Exon Count: 9 Strand: -
Coding Region
Position: hg38 chr12:43,730,376-43,755,245 Size: 24,870 Coding Exon Count: 8
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PUS7L_HUMAN
DESCRIPTION: RecName: Full=Pseudouridylate synthase 7 homolog-like protein; EC=5.4.99.-;
CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.SIMILARITY: Belongs to the pseudouridine synthase TruD family.SIMILARITY: Contains 1 TRUD domain.SEQUENCE CAUTION: Sequence=AAH20781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR020103 - PsdUridine_synth_cat_dom
IPR001656 - PsdUridine_synth_TruD
IPR017091 - PsdUridine_synth_TruD_euk
IPR011760 - PsdUridine_synth_TruD_insert
Pfam Domains: PF01142 - tRNA pseudouridine synthase D (TruD)
ModBase Predicted Comparative 3D Structure on Q9H0K6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX647494 - Homo sapiens mRNA; cDNA DKFZp686P10128 (from clone DKFZp686P10128).BC068502 - Homo sapiens pseudouridylate synthase 7 homolog (S. cerevisiae)-like, mRNA (cDNA clone MGC:87243 IMAGE:5259952), complete cds.AL136759 - Homo sapiens mRNA; cDNA DKFZp434G1415 (from clone DKFZp434G1415); complete cds.JD345124 - Sequence 326148 from Patent EP1572962.JD277938 - Sequence 258962 from Patent EP1572962.JD355975 - Sequence 336999 from Patent EP1572962.JD356063 - Sequence 337087 from Patent EP1572962.JD324662 - Sequence 305686 from Patent EP1572962.JD468003 - Sequence 449027 from Patent EP1572962.JD245051 - Sequence 226075 from Patent EP1572962.JD185604 - Sequence 166628 from Patent EP1572962.JD058617 - Sequence 39641 from Patent EP1572962.CR627435 - Homo sapiens mRNA; cDNA DKFZp781B2386 (from clone DKFZp781B2386).JD133461 - Sequence 114485 from Patent EP1572962.AK097331 - Homo sapiens cDNA FLJ40012 fis, clone STOMA2005782, weakly similar to Pseudouridylate synthase 7 homolog (EC 5.4.99.-).BC033621 - Homo sapiens pseudouridylate synthase 7 homolog (S. cerevisiae)-like, mRNA (cDNA clone MGC:40389 IMAGE:5195232), complete cds.AK225903 - Homo sapiens mRNA for hypothetical protein LOC83448 variant, clone: FCC120B04.AK092030 - Homo sapiens cDNA FLJ34711 fis, clone MESAN2003444, weakly similar to 39.1 KDA PROTEIN IN SURE-CYSC INTERGENIC REGION.AX747323 - Sequence 848 from Patent EP1308459.KJ899701 - Synthetic construct Homo sapiens clone ccsbBroadEn_09095 PUS7L gene, encodes complete protein.KJ899702 - Synthetic construct Homo sapiens clone ccsbBroadEn_09096 PUS7L gene, encodes complete protein.AB527251 - Synthetic construct DNA, clone: pF1KE0005, Homo sapiens PUS7L gene for pseudouridylate synthase 7 homolog (S. cerevisiae)-like, without stop codon, in Flexi system.AM392971 - Synthetic construct Homo sapiens clone IMAGE:100001774 for hypothetical protein (PUS7L gene).BC020781 - Homo sapiens pseudouridylate synthase 7 homolog (S. cerevisiae)-like, mRNA (cDNA clone IMAGE:4719235), partial cds.BC018000 - Homo sapiens pseudouridylate synthase 7 homolog (S. cerevisiae)-like, mRNA (cDNA clone IMAGE:4254137).CU686653 - Synthetic construct Homo sapiens gateway clone IMAGE:100022860 5' read PUS7L mRNA.JD163317 - Sequence 144341 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: BX647494, ENST00000416848.1, ENST00000416848.2, ENST00000416848.3, ENST00000416848.4, ENST00000416848.5, PUS7L_HUMAN, Q05CU0, Q6AHZ3, Q6NUP2, Q9H0K6, uc001rnq.1, uc001rnq.2, uc001rnq.3, uc001rnq.4, uc001rnq.5, uc001rnq.6, uc001rnq.7UCSC ID: ENST00000416848.6RefSeq Accession: NM_001098615
Protein: Q9H0K6
(aka PUS7L_HUMAN)
CCDS: CCDS8743.1
Methods, Credits, and Use Restrictions
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