Human Gene C12orf41 (uc001rrx.2) Description and Page Index
  Description: hypothetical protein LOC54934
Transcript (Including UTRs)
   Position: hg18 chr12:47,333,262-47,362,302 Size: 29,041 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg18 chr12:47,334,094-47,361,682 Size: 27,589 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:47,333,262-47,362,302)mRNA (may differ from genome)Protein (492 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDMGIOMIMPubMedReactome
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: KANL2_HUMAN
DESCRIPTION: RecName: Full=KAT8 regulatory NSL complex subunit 2; AltName: Full=NSL complex protein NSL2; AltName: Full=Non-specific lethal 2 homolog;
FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
SUBUNIT: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
SUBCELLULAR LOCATION: Nucleus.
SEQUENCE CAUTION: Sequence=AAH09746.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH13900.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91169.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB14211.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD39126.1; Type=Erroneous translation; Note=Wrong choice of CDS;

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.9075-0.399 Picture PostScript Text
3' UTR -231.60832-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026316 - NSL2
IPR025927 - Potential_DNA-bd

ModBase Predicted Comparative 3D Structure on Q9H9L4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
MGIRGDEnsemblFlyBase  
Protein Sequence Protein SequenceProtein Sequence  
Alignment AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)

Biological Process:
GO:0006325 chromatin organization
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AL834467 - Homo sapiens mRNA; cDNA DKFZp762L0110 (from clone DKFZp762L0110).
AK000443 - Homo sapiens cDNA FLJ20436 fis, clone KAT03972.
AK094528 - Homo sapiens cDNA FLJ37209 fis, clone BRALZ2007793, moderately similar to Xenopus laevis 4g2 mRNA.
BC009746 - Homo sapiens chromosome 12 open reading frame 41, mRNA (cDNA clone MGC:1043 IMAGE:3503970), complete cds.
BC013900 - Homo sapiens chromosome 12 open reading frame 41, mRNA (cDNA clone MGC:15026 IMAGE:3928141), complete cds.
AK022732 - Homo sapiens cDNA FLJ12670 fis, clone NT2RM4002301.
JD566239 - Sequence 547263 from Patent EP1572962.
JD507143 - Sequence 488167 from Patent EP1572962.
JD349966 - Sequence 330990 from Patent EP1572962.
JD435902 - Sequence 416926 from Patent EP1572962.
JD530099 - Sequence 511123 from Patent EP1572962.
JD354614 - Sequence 335638 from Patent EP1572962.
JD279982 - Sequence 261006 from Patent EP1572962.
JD064345 - Sequence 45369 from Patent EP1572962.
JD221198 - Sequence 202222 from Patent EP1572962.
JD315931 - Sequence 296955 from Patent EP1572962.
JD085017 - Sequence 66041 from Patent EP1572962.
JD260247 - Sequence 241271 from Patent EP1572962.
JD209337 - Sequence 190361 from Patent EP1572962.
JD092428 - Sequence 73452 from Patent EP1572962.
JD247237 - Sequence 228261 from Patent EP1572962.
JD328864 - Sequence 309888 from Patent EP1572962.
JD130835 - Sequence 111859 from Patent EP1572962.
JD121191 - Sequence 102215 from Patent EP1572962.
JD042891 - Sequence 23915 from Patent EP1572962.
JD309805 - Sequence 290829 from Patent EP1572962.
JD181662 - Sequence 162686 from Patent EP1572962.
JD143604 - Sequence 124628 from Patent EP1572962.
JD048031 - Sequence 29055 from Patent EP1572962.
LF385074 - JP 2014500723-A/192577: Polycomb-Associated Non-Coding RNAs.
LF337823 - JP 2014500723-A/145326: Polycomb-Associated Non-Coding RNAs.
LF337824 - JP 2014500723-A/145327: Polycomb-Associated Non-Coding RNAs.
LF337829 - JP 2014500723-A/145332: Polycomb-Associated Non-Coding RNAs.
LF337834 - JP 2014500723-A/145337: Polycomb-Associated Non-Coding RNAs.
LF337835 - JP 2014500723-A/145338: Polycomb-Associated Non-Coding RNAs.
LF337838 - JP 2014500723-A/145341: Polycomb-Associated Non-Coding RNAs.
LF337840 - JP 2014500723-A/145343: Polycomb-Associated Non-Coding RNAs.
MA620651 - JP 2018138019-A/192577: Polycomb-Associated Non-Coding RNAs.
MA573400 - JP 2018138019-A/145326: Polycomb-Associated Non-Coding RNAs.
MA573401 - JP 2018138019-A/145327: Polycomb-Associated Non-Coding RNAs.
MA573406 - JP 2018138019-A/145332: Polycomb-Associated Non-Coding RNAs.
MA573411 - JP 2018138019-A/145337: Polycomb-Associated Non-Coding RNAs.
MA573412 - JP 2018138019-A/145338: Polycomb-Associated Non-Coding RNAs.
MA573415 - JP 2018138019-A/145341: Polycomb-Associated Non-Coding RNAs.
MA573417 - JP 2018138019-A/145343: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H9L4 (Reactome details) participates in the following event(s):

R-HSA-3321805 NSL acetylates histone H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: CL041_HUMAN, NM_017822, NP_060292, Q8N3B5, Q96CV0, Q9H9L4, Q9NX51, uc001rrx.1
UCSC ID: uc001rrx.2
RefSeq Accession: NM_017822
Protein: Q9H9L4 (aka KANL2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017822.3
exon count: 10CDS single in 3' UTR: no RNA size: 2402
ORF size: 1479CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3157.50frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.