Human Gene RND1 (ENST00000309739.6) from GENCODE V44
  Description: Homo sapiens Rho family GTPase 1 (RND1), mRNA. (from RefSeq NM_014470)
RefSeq Summary (NM_014470): This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014].
Gencode Transcript: ENST00000309739.6
Gencode Gene: ENSG00000172602.11
Transcript (Including UTRs)
   Position: hg38 chr12:48,857,145-48,865,870 Size: 8,726 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr12:48,857,996-48,865,767 Size: 7,772 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:48,857,145-48,865,870)mRNA (may differ from genome)Protein (232 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RND1_HUMAN
DESCRIPTION: RecName: Full=Rho-related GTP-binding protein Rho6; AltName: Full=Rho family GTPase 1; AltName: Full=Rnd1; Flags: Precursor;
FUNCTION: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
SUBUNIT: Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2.
INTERACTION: Q14451:GRB7; NbExp=4; IntAct=EBI-448618, EBI-970191;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Mostly expressed in brain and liver.
SIMILARITY: Belongs to the small GTPase superfamily. Rho family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RND1
Diseases sorted by gene-association score: alcohol-induced mental disorder (2), alcoholic psychosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.49 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 217.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.10103-0.312 Picture PostScript Text
3' UTR -342.50851-0.402 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003578 - Small_GTPase_Rho

Pfam Domains:
PF00071 - Ras family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CLS - X-ray MuPIT 2REX - X-ray MuPIT 3Q3J - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q92730
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0007015 actin filament organization
GO:0007162 negative regulation of cell adhesion
GO:0007264 small GTPase mediated signal transduction
GO:0016322 neuron remodeling

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF210429 - JP 2014500723-A/17932: Polycomb-Associated Non-Coding RNAs.
MA446006 - JP 2018138019-A/17932: Polycomb-Associated Non-Coding RNAs.
BC026356 - Homo sapiens Rho family GTPase 1, mRNA (cDNA clone MGC:26932 IMAGE:4793442), complete cds.
AK124288 - Homo sapiens cDNA FLJ42294 fis, clone TLIVE2008083.
AL359573 - Homo sapiens mRNA; cDNA DKFZp547J193 (from clone DKFZp547J193).
JD493185 - Sequence 474209 from Patent EP1572962.
JD123949 - Sequence 104973 from Patent EP1572962.
JD513189 - Sequence 494213 from Patent EP1572962.
JD239321 - Sequence 220345 from Patent EP1572962.
JD471692 - Sequence 452716 from Patent EP1572962.
JD288473 - Sequence 269497 from Patent EP1572962.
JD287956 - Sequence 268980 from Patent EP1572962.
JD372158 - Sequence 353182 from Patent EP1572962.
JD356066 - Sequence 337090 from Patent EP1572962.
AK292762 - Homo sapiens cDNA FLJ76081 complete cds, highly similar to Homo sapiens Rho family GTPase 1 (RND1), mRNA.
JD475746 - Sequence 456770 from Patent EP1572962.
AB040147 - Homo sapiens mRNA for Rnd1, complete cds.
JD317856 - Sequence 298880 from Patent EP1572962.
JD218689 - Sequence 199713 from Patent EP1572962.
JD248437 - Sequence 229461 from Patent EP1572962.
JD566562 - Sequence 547586 from Patent EP1572962.
JD377604 - Sequence 358628 from Patent EP1572962.
JD544562 - Sequence 525586 from Patent EP1572962.
AF498967 - Homo sapiens small GTP binding protein Rho6 (Rho6) mRNA, complete cds.
Y07923 - H.sapiens mRNA for Rho6 protein.
KJ893623 - Synthetic construct Homo sapiens clone ccsbBroadEn_03017 RND1 gene, encodes complete protein.
AB464152 - Synthetic construct DNA, clone: pF1KB5344, Homo sapiens RND1 gene for Rho family GTPase 1, without stop codon, in Flexi system.
LF337867 - JP 2014500723-A/145370: Polycomb-Associated Non-Coding RNAs.
MA573444 - JP 2018138019-A/145370: Polycomb-Associated Non-Coding RNAs.
LF212637 - JP 2014500723-A/20140: Polycomb-Associated Non-Coding RNAs.
MA448214 - JP 2018138019-A/20140: Polycomb-Associated Non-Coding RNAs.
JD398155 - Sequence 379179 from Patent EP1572962.
JD343242 - Sequence 324266 from Patent EP1572962.
JD234542 - Sequence 215566 from Patent EP1572962.
JD348606 - Sequence 329630 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04360 - Axon guidance

Reactome (by CSHL, EBI, and GO)

Protein Q92730 (Reactome details) participates in the following event(s):

R-HSA-416594 LARG and PDZ-RhoGEF binds to Plexin-B1
R-HSA-399928 Recruitment of Rnd1 to Plexin A
R-HSA-400677 Rnd1 interacts with Plexin-B1:Sema4D
R-HSA-416562 p190RhoGAP binds Plexin-B1
R-HSA-416588 Activation of Rho by LARG and PDZ-RhoGEF
R-HSA-399935 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
R-HSA-416546 Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
R-HSA-416559 Inactivation of Rho-GTP by p190RhoGAP
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-373755 Semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9P7, ENST00000309739.1, ENST00000309739.2, ENST00000309739.3, ENST00000309739.4, ENST00000309739.5, NM_014470, Q92730, RHO6, RND1_HUMAN, uc001rsn.1, uc001rsn.2, uc001rsn.3, uc001rsn.4, uc001rsn.5
UCSC ID: ENST00000309739.6
RefSeq Accession: NM_014470
Protein: Q92730 (aka RND1_HUMAN)
CCDS: CCDS8771.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.