Human Gene RND1 (ENST00000309739.6) from GENCODE V44
Description: Homo sapiens Rho family GTPase 1 (RND1), mRNA. (from RefSeq NM_014470) RefSeq Summary (NM_014470): This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]. Gencode Transcript: ENST00000309739.6 Gencode Gene: ENSG00000172602.11 Transcript (Including UTRs) Position: hg38 chr12:48,857,145-48,865,870 Size: 8,726 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr12:48,857,996-48,865,767 Size: 7,772 Coding Exon Count: 5
ID:RND1_HUMAN DESCRIPTION: RecName: Full=Rho-related GTP-binding protein Rho6; AltName: Full=Rho family GTPase 1; AltName: Full=Rnd1; Flags: Precursor; FUNCTION: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. SUBUNIT: Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2. INTERACTION: Q14451:GRB7; NbExp=4; IntAct=EBI-448618, EBI-970191; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Mostly expressed in brain and liver. SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92730
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF210429 - JP 2014500723-A/17932: Polycomb-Associated Non-Coding RNAs. MA446006 - JP 2018138019-A/17932: Polycomb-Associated Non-Coding RNAs. BC026356 - Homo sapiens Rho family GTPase 1, mRNA (cDNA clone MGC:26932 IMAGE:4793442), complete cds. AK124288 - Homo sapiens cDNA FLJ42294 fis, clone TLIVE2008083. AL359573 - Homo sapiens mRNA; cDNA DKFZp547J193 (from clone DKFZp547J193). JD493185 - Sequence 474209 from Patent EP1572962. JD123949 - Sequence 104973 from Patent EP1572962. JD513189 - Sequence 494213 from Patent EP1572962. JD239321 - Sequence 220345 from Patent EP1572962. JD471692 - Sequence 452716 from Patent EP1572962. JD288473 - Sequence 269497 from Patent EP1572962. JD287956 - Sequence 268980 from Patent EP1572962. JD372158 - Sequence 353182 from Patent EP1572962. JD356066 - Sequence 337090 from Patent EP1572962. AK292762 - Homo sapiens cDNA FLJ76081 complete cds, highly similar to Homo sapiens Rho family GTPase 1 (RND1), mRNA. JD475746 - Sequence 456770 from Patent EP1572962. AB040147 - Homo sapiens mRNA for Rnd1, complete cds. JD317856 - Sequence 298880 from Patent EP1572962. JD218689 - Sequence 199713 from Patent EP1572962. JD248437 - Sequence 229461 from Patent EP1572962. JD566562 - Sequence 547586 from Patent EP1572962. JD377604 - Sequence 358628 from Patent EP1572962. JD544562 - Sequence 525586 from Patent EP1572962. AF498967 - Homo sapiens small GTP binding protein Rho6 (Rho6) mRNA, complete cds. Y07923 - H.sapiens mRNA for Rho6 protein. KJ893623 - Synthetic construct Homo sapiens clone ccsbBroadEn_03017 RND1 gene, encodes complete protein. AB464152 - Synthetic construct DNA, clone: pF1KB5344, Homo sapiens RND1 gene for Rho family GTPase 1, without stop codon, in Flexi system. LF337867 - JP 2014500723-A/145370: Polycomb-Associated Non-Coding RNAs. MA573444 - JP 2018138019-A/145370: Polycomb-Associated Non-Coding RNAs. LF212637 - JP 2014500723-A/20140: Polycomb-Associated Non-Coding RNAs. MA448214 - JP 2018138019-A/20140: Polycomb-Associated Non-Coding RNAs. JD398155 - Sequence 379179 from Patent EP1572962. JD343242 - Sequence 324266 from Patent EP1572962. JD234542 - Sequence 215566 from Patent EP1572962. JD348606 - Sequence 329630 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04360 - Axon guidance
Reactome (by CSHL, EBI, and GO)
Protein Q92730 (Reactome details) participates in the following event(s):
R-HSA-416594 LARG and PDZ-RhoGEF binds to Plexin-B1 R-HSA-399928 Recruitment of Rnd1 to Plexin A R-HSA-400677 Rnd1 interacts with Plexin-B1:Sema4D R-HSA-416562 p190RhoGAP binds Plexin-B1 R-HSA-416588 Activation of Rho by LARG and PDZ-RhoGEF R-HSA-399935 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity R-HSA-416546 Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity R-HSA-416559 Inactivation of Rho-GTP by p190RhoGAP R-HSA-416572 Sema4D induced cell migration and growth-cone collapse R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration R-HSA-400685 Sema4D in semaphorin signaling R-HSA-373755 Semaphorin interactions R-HSA-422475 Axon guidance R-HSA-1266738 Developmental Biology