Human Gene COQ10A (ENST00000308197.10) from GENCODE V44
  Description: Homo sapiens coenzyme Q10A (COQ10A), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_144576)
Gencode Transcript: ENST00000308197.10
Gencode Gene: ENSG00000135469.14
Transcript (Including UTRs)
   Position: hg38 chr12:56,266,942-56,270,966 Size: 4,025 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr12:56,267,119-56,270,317 Size: 3,199 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,266,942-56,270,966)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CQ10A_HUMAN
DESCRIPTION: RecName: Full=Coenzyme Q-binding protein COQ10 homolog A, mitochondrial; Flags: Precursor;
FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).
SUBUNIT: Interacts with coenzyme Q (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the COQ10 family.
SEQUENCE CAUTION: Sequence=AAQ89220.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 55.87 RPKM in Heart - Left Ventricle
Total median expression: 444.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.60177-0.416 Picture PostScript Text
3' UTR -187.90649-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005031 - Polyket_cyc
IPR023393 - START-like_dom

Pfam Domains:
PF03364 - Polyketide cyclase / dehydrase and lipid transport

ModBase Predicted Comparative 3D Structure on Q96MF6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0048039 ubiquinone binding

Biological Process:
GO:0006744 ubiquinone biosynthetic process
GO:0045333 cellular respiration

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK057003 - Homo sapiens cDNA FLJ32441 fis, clone SKMUS2001501.
BC073923 - Homo sapiens coenzyme Q10 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:90430 IMAGE:5188138), complete cds.
JD040904 - Sequence 21928 from Patent EP1572962.
JD387574 - Sequence 368598 from Patent EP1572962.
JD125008 - Sequence 106032 from Patent EP1572962.
JD461780 - Sequence 442804 from Patent EP1572962.
BC047444 - Homo sapiens coenzyme Q10 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:5299314), partial cds.
AY358861 - Homo sapiens clone DNA142949 RFLT6192 (UNQ6192) mRNA, complete cds.
BC026922 - Homo sapiens coenzyme Q10 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:4708598), partial cds.
LF384697 - JP 2014500723-A/192200: Polycomb-Associated Non-Coding RNAs.
MA620274 - JP 2018138019-A/192200: Polycomb-Associated Non-Coding RNAs.
AK057014 - Homo sapiens cDNA FLJ32452 fis, clone SKMUS2001671.
BC002435 - Homo sapiens coenzyme Q10 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:3346451), partial cds.
LF208958 - JP 2014500723-A/16461: Polycomb-Associated Non-Coding RNAs.
MA444535 - JP 2018138019-A/16461: Polycomb-Associated Non-Coding RNAs.
JD412595 - Sequence 393619 from Patent EP1572962.
JD090495 - Sequence 71519 from Patent EP1572962.
LF324482 - JP 2014500723-A/131985: Polycomb-Associated Non-Coding RNAs.
MA560059 - JP 2018138019-A/131985: Polycomb-Associated Non-Coding RNAs.
JD349422 - Sequence 330446 from Patent EP1572962.
JD490962 - Sequence 471986 from Patent EP1572962.
JD239873 - Sequence 220897 from Patent EP1572962.
JD440048 - Sequence 421072 from Patent EP1572962.
JD328115 - Sequence 309139 from Patent EP1572962.
JD064154 - Sequence 45178 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CQ10A_HUMAN, ENST00000308197.1, ENST00000308197.2, ENST00000308197.3, ENST00000308197.4, ENST00000308197.5, ENST00000308197.6, ENST00000308197.7, ENST00000308197.8, ENST00000308197.9, NM_144576, Q6GMR6, Q6UWB9, Q86X16, Q96MF1, Q96MF6, Q9BUP4, uc001sko.1, uc001sko.2, uc001sko.3, uc001sko.4, uc001sko.5, uc001sko.6, UNQ6192/PRO20219
UCSC ID: ENST00000308197.10
RefSeq Accession: NM_144576
Protein: Q96MF6 (aka CQ10A_HUMAN)
CCDS: CCDS41796.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.