Human Gene KCNC2 (ENST00000298972.5) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily C member 2 (KCNC2), transcript variant 1, mRNA. (from RefSeq NM_139136) RefSeq Summary (NM_139136): The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000298972.5 Gencode Gene: ENSG00000166006.14 Transcript (Including UTRs) Position: hg38 chr12:75,040,080-75,209,748 Size: 169,669 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr12:75,042,313-75,207,983 Size: 165,671 Coding Exon Count: 4
ID:KCNC2_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily C member 2; AltName: Full=Voltage-gated potassium channel Kv3.2; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity). SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. DOMAIN: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. SIMILARITY: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. SEQUENCE CAUTION: Sequence=BAE06076.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain
ModBase Predicted Comparative 3D Structure on Q96PR1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005251 delayed rectifier potassium channel activity GO:0005267 potassium channel activity GO:0044325 ion channel binding
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0009636 response to toxic substance GO:0009642 response to light intensity GO:0014070 response to organic cyclic compound GO:0014075 response to amine GO:0021759 globus pallidus development GO:0032026 response to magnesium ion GO:0034220 ion transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0038060 nitric oxide-cGMP-mediated signaling pathway GO:0045471 response to ethanol GO:0050796 regulation of insulin secretion GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization GO:0055085 transmembrane transport GO:0071242 cellular response to ammonium ion GO:0071732 cellular response to nitric oxide GO:0071805 potassium ion transmembrane transport GO:0097237 cellular response to toxic substance GO:1901381 positive regulation of potassium ion transmembrane transport GO:1903818 positive regulation of voltage-gated potassium channel activity GO:1990089 response to nerve growth factor