Human Gene OSBPL8 (ENST00000261183.8) from GENCODE V44
Description: Homo sapiens oxysterol binding protein like 8 (OSBPL8), transcript variant 1, mRNA. (from RefSeq NM_020841) RefSeq Summary (NM_020841): This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. Gencode Transcript: ENST00000261183.8 Gencode Gene: ENSG00000091039.17 Transcript (Including UTRs) Position: hg38 chr12:76,351,797-76,559,771 Size: 207,975 Total Exon Count: 24 Strand: - Coding Region Position: hg38 chr12:76,355,889-76,487,551 Size: 131,663 Coding Exon Count: 23
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZF1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006869 lipid transport GO:0010891 negative regulation of sequestering of triglyceride GO:0015914 phospholipid transport GO:0030336 negative regulation of cell migration GO:0032148 activation of protein kinase B activity GO:0036150 phosphatidylserine acyl-chain remodeling GO:0045444 fat cell differentiation GO:0046628 positive regulation of insulin receptor signaling pathway GO:0051897 positive regulation of protein kinase B signaling GO:0090204 protein localization to nuclear pore GO:2001275 positive regulation of glucose import in response to insulin stimulus
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
