Human Gene SSH1 (ENST00000326495.10) from GENCODE V44
Description: Homo sapiens slingshot protein phosphatase 1 (SSH1), transcript variant 1, mRNA. (from RefSeq NM_018984) RefSeq Summary (NM_018984): The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000326495.10 Gencode Gene: ENSG00000084112.15 Transcript (Including UTRs) Position: hg38 chr12:108,778,191-108,857,583 Size: 79,393 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr12:108,787,988-108,857,496 Size: 69,509 Coding Exon Count: 15
ID:SSH1_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase Slingshot homolog 1; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=SSH-like protein 1; Short=SSH-1L; Short=hSSH-1L; FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBUNIT: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin. INTERACTION: Q9BR76:CORO1B; NbExp=3; IntAct=EBI-1222387, EBI-351152; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis. PTM: Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase. MISCELLANEOUS: Tyrosine phosphatase activity has not been demonstrated for this protein to date. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. SEQUENCE CAUTION: Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08766 - DEK C terminal domain PF00782 - Dual specificity phosphatase, catalytic domain
ModBase Predicted Comparative 3D Structure on Q8WYL5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.