Human Gene RNFT2 (ENST00000407967.7) from GENCODE V44
  Description: Homo sapiens ring finger protein, transmembrane 2 (RNFT2), transcript variant 2, mRNA. (from RefSeq NM_032814)
Gencode Transcript: ENST00000407967.7
Gencode Gene: ENSG00000135119.15
Transcript (Including UTRs)
   Position: hg38 chr12:116,738,291-116,853,631 Size: 115,341 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr12:116,740,498-116,852,712 Size: 112,215 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:116,738,291-116,853,631)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RNFT2_HUMAN
DESCRIPTION: RecName: Full=RING finger and transmembrane domain-containing protein 2;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH11878.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.34 RPKM in Brain - Cerebellum
Total median expression: 62.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.20233-0.336 Picture PostScript Text
3' UTR -249.70919-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF13639 - Ring finger domain

ModBase Predicted Comparative 3D Structure on Q96EX2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC011878 - Homo sapiens ring finger protein, transmembrane 2, mRNA (cDNA clone MGC:20447 IMAGE:3532898), complete cds.
AK027533 - Homo sapiens cDNA FLJ14627 fis, clone NT2RP2000289.
KJ904925 - Synthetic construct Homo sapiens clone ccsbBroadEn_14319 RNFT2-like gene, encodes complete protein.
AK093164 - Homo sapiens cDNA FLJ35845 fis, clone TESTI2006853.
AX747967 - Sequence 1492 from Patent EP1308459.
JD152601 - Sequence 133625 from Patent EP1572962.
JD051666 - Sequence 32690 from Patent EP1572962.
JD155042 - Sequence 136066 from Patent EP1572962.
JD123237 - Sequence 104261 from Patent EP1572962.
JD408671 - Sequence 389695 from Patent EP1572962.
JD121536 - Sequence 102560 from Patent EP1572962.
JD115562 - Sequence 96586 from Patent EP1572962.
JD364814 - Sequence 345838 from Patent EP1572962.
JD364815 - Sequence 345839 from Patent EP1572962.
JD117668 - Sequence 98692 from Patent EP1572962.
JD409769 - Sequence 390793 from Patent EP1572962.
JD500278 - Sequence 481302 from Patent EP1572962.
JD554834 - Sequence 535858 from Patent EP1572962.
AK094682 - Homo sapiens cDNA FLJ37363 fis, clone BRAMY2024073.
AY358585 - Homo sapiens clone DNA59493 WLPL514 (UNQ514) mRNA, complete cds.
JD304100 - Sequence 285124 from Patent EP1572962.
JD304101 - Sequence 285125 from Patent EP1572962.
JD506888 - Sequence 487912 from Patent EP1572962.
JD080736 - Sequence 61760 from Patent EP1572962.
JD258015 - Sequence 239039 from Patent EP1572962.
JD552468 - Sequence 533492 from Patent EP1572962.
JD104118 - Sequence 85142 from Patent EP1572962.
JD202571 - Sequence 183595 from Patent EP1572962.
JD201028 - Sequence 182052 from Patent EP1572962.
JD221317 - Sequence 202341 from Patent EP1572962.
JD338941 - Sequence 319965 from Patent EP1572962.
JD055944 - Sequence 36968 from Patent EP1572962.
JD137520 - Sequence 118544 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000407967.1, ENST00000407967.2, ENST00000407967.3, ENST00000407967.4, ENST00000407967.5, ENST00000407967.6, NM_032814, Q96EX2, Q96SU5, RNFT2_HUMAN, TMEM118, uc001twb.1, uc001twb.2, uc001twb.3, uc001twb.4
UCSC ID: ENST00000407967.7
RefSeq Accession: NM_001109903
Protein: Q96EX2 (aka RNFT2_HUMAN)
CCDS: CCDS9180.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.