Human Gene RPLP0 (ENST00000228306.8)
  Description: Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 2, mRNA. (from RefSeq NM_053275)
RefSeq Summary (NM_053275): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000228306.8
Gencode Gene: ENSG00000089157.16
Transcript (Including UTRs)
   Position: hg38 chr12:120,196,707-120,201,211 Size: 4,505 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr12:120,196,773-120,200,783 Size: 4,011 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:120,196,707-120,201,211)mRNA (may differ from genome)Protein (317 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=60S acidic ribosomal protein P0; AltName: Full=60S ribosomal protein L10E;
FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
SUBUNIT: P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with Lassa virus Z protein. Interacts with APEX1.
INTERACTION: O95793:STAU1; NbExp=4; IntAct=EBI-354101, EBI-358174;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
SIMILARITY: Belongs to the ribosomal protein L10P family.

-  MalaCards Disease Associations
  MalaCards Gene Search: RPLP0
Diseases sorted by gene-association score: charcot-marie-tooth disease, axonal, type 2l (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1452.62 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 23502.03 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.70237-0.353 Picture PostScript Text
3' UTR -8.0066-0.121 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001813 - Ribosomal_60S
IPR001790 - Ribosomal_L10/acidic_P0

Pfam Domains:
PF00428 - 60s Acidic ribosomal protein
PF00466 - Ribosomal protein L10

ModBase Predicted Comparative 3D Structure on P05388
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein Sequence Protein SequenceProtein SequenceProtein Sequence
AlignmentAlignment AlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding

Biological Process:
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0016032 viral process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

-  Descriptions from all associated GenBank mRNAs
  AK129823 - Homo sapiens cDNA FLJ26313 fis, clone DMC08902, highly similar to 60S acidic ribosomal protein P0.
BC019014 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone IMAGE:4583368).
AF274958 - Homo sapiens PNAS-101 mRNA, complete cds.
BC001127 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:2266 IMAGE:2987976), complete cds.
BC008594 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:17555 IMAGE:3463159), complete cds.
BC000345 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:8574 IMAGE:2960918), complete cds.
BC000752 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:2461 IMAGE:2964581), complete cds.
BC001834 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:4141 IMAGE:2964581), complete cds.
BC005863 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:3679 IMAGE:2960918), complete cds.
BC008092 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:9343 IMAGE:3458803), complete cds.
BC009867 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:16401 IMAGE:3940316), complete cds.
BC015690 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:23431 IMAGE:4660892), complete cds.
BC071911 - Homo sapiens cDNA clone IMAGE:6569344, **** WARNING: chimeric clone ****.
BC003655 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:4770 IMAGE:3541947), complete cds.
BC000087 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:3280 IMAGE:3507437), complete cds.
BC107717 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:111226 IMAGE:6736210), complete cds.
AK222468 - Homo sapiens mRNA for ribosomal protein P0 variant, clone: adKA01530.
AK129754 - Homo sapiens cDNA FLJ26243 fis, clone DMC00801, highly similar to 60S acidic ribosomal protein P0.
AK304674 - Homo sapiens cDNA FLJ51469 complete cds, highly similar to 60S acidic ribosomal protein P0.
AK291109 - Homo sapiens cDNA FLJ75549 complete cds, highly similar to Homo sapiens ribosomal protein, large, P0 (RPLP0), transcript variant 1, mRNA.
AK001313 - Homo sapiens cDNA FLJ10451 fis, clone NT2RP1000959, highly similar to Human acidic ribosomal phosphoprotein P0 mRNA.
M17885 - Human acidic ribosomal phosphoprotein P0 mRNA, complete cds.
BC070194 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:88175 IMAGE:6457312), complete cds.
BC104645 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone IMAGE:4667742), partial cds.
AK222571 - Homo sapiens mRNA for ribosomal protein P0 variant, clone: CAS03712.
BC015173 - Homo sapiens ribosomal protein, large, P0, mRNA (cDNA clone MGC:10138 IMAGE:3903073), complete cds.
JD351154 - Sequence 332178 from Patent EP1572962.
DQ891813 - Synthetic construct clone IMAGE:100004443; FLH180173.01X; RZPDo839G12132D ribosomal protein, large, P0 (RPLP0) gene, encodes complete protein.
KJ892047 - Synthetic construct Homo sapiens clone ccsbBroadEn_01441 RPLP0 gene, encodes complete protein.
KJ897493 - Synthetic construct Homo sapiens clone ccsbBroadEn_06887 RPLP0 gene, encodes complete protein.
DQ894996 - Synthetic construct Homo sapiens clone IMAGE:100009456; FLH180169.01L; RZPDo839G12131D ribosomal protein, large, P0 (RPLP0) gene, encodes complete protein.
KJ905905 - Synthetic construct Homo sapiens clone ccsbBroadEn_15575 RPLP0 gene, encodes complete protein.
AB464171 - Synthetic construct DNA, clone: pF1KB8219, Homo sapiens RPLP0 gene for ribosomal protein, large, P0, without stop codon, in Flexi system.
JD019719 - Sequence 743 from Patent EP1572962.
CU674564 - Synthetic construct Homo sapiens gateway clone IMAGE:100018879 5' read RPLP0 mRNA.
JD020420 - Sequence 1444 from Patent EP1572962.
DL492076 - Novel nucleic acids.
CU678560 - Synthetic construct Homo sapiens gateway clone IMAGE:100017017 5' read RPLP0 mRNA.
DL490622 - Novel nucleic acids.
Z36785 - H.sapiens (xs13) mRNA, 284bp.
DL491807 - Novel nucleic acids.
DL490382 - Novel nucleic acids.
D28418 - Homo sapiens mRNA for ribosomal phosphoprotein P0, 5'UTR region.
JD495347 - Sequence 476371 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03010 - Ribosome

Reactome (by CSHL, EBI, and GO)

Protein P05388 (Reactome details) participates in the following event(s):

R-HSA-72672 The 60S subunit joins the translation initiation complex
R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit
R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome
R-HSA-72671 eIF5B:GTP is hydrolyzed and released
R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site
R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction
R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA
R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex
R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
R-HSA-156923 Hydrolysis of eEF1A:GTP
R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-156827 L13a-mediated translation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-9020591 Interleukin-12 signaling
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-447115 Interleukin-12 family signaling
R-HSA-156902 Peptide chain elongation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-72766 Translation
R-HSA-376176 Signaling by ROBO receptors
R-HSA-192823 Viral mRNA Translation
R-HSA-72312 rRNA processing
R-HSA-449147 Signaling by Interleukins
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-8953854 Metabolism of RNA
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1266738 Developmental Biology
R-HSA-168255 Influenza Life Cycle
R-HSA-168256 Immune System
R-HSA-1430728 Metabolism
R-HSA-168254 Influenza Infection
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000228306.1, ENST00000228306.2, ENST00000228306.3, ENST00000228306.4, ENST00000228306.5, ENST00000228306.6, ENST00000228306.7, NM_053275, P05388, Q9BVK4, RLA0_HUMAN, uc001txp.1, uc001txp.2, uc001txp.3, uc001txp.4
UCSC ID: ENST00000228306.8
RefSeq Accession: NM_053275
Protein: P05388 (aka RLA0_HUMAN)
CCDS: CCDS9193.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.