Human Gene RPLP0 (ENST00000228306.8) Description and Page Index
Description: Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 2, mRNA. (from RefSeq NM_053275) RefSeq Summary (NM_053275): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000228306.8 Gencode Gene: ENSG00000089157.16 Transcript (Including UTRs) Position: hg38 chr12:120,196,707-120,201,211 Size: 4,505 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr12:120,196,773-120,200,783 Size: 4,011 Coding Exon Count: 7
ID:RLA0_HUMAN DESCRIPTION: RecName: Full=60S acidic ribosomal protein P0; AltName: Full=60S ribosomal protein L10E; FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli protein L10. SUBUNIT: P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with Lassa virus Z protein. Interacts with APEX1. INTERACTION: O95793:STAU1; NbExp=4; IntAct=EBI-354101, EBI-358174; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. SIMILARITY: Belongs to the ribosomal protein L10P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00428 - 60s Acidic ribosomal protein PF00466 - Ribosomal protein L10
ModBase Predicted Comparative 3D Structure on P05388
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.