Human Gene HCAR1 (ENST00000432564.3) from GENCODE V44
Description: Homo sapiens hydroxycarboxylic acid receptor 1 (HCAR1), mRNA. (from RefSeq NM_032554)
RefSeq Summary (NM_032554): G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005].
Gencode Transcript: ENST00000432564.3
Gencode Gene: ENSG00000196917.6
Transcript (Including UTRs)
Position: hg38 chr12:122,726,076-122,730,844 Size: 4,769 Total Exon Count: 1 Strand: -
Coding Region
Position: hg38 chr12:122,729,299-122,730,339 Size: 1,041 Coding Exon Count: 1
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: HCAR1_HUMAN
DESCRIPTION: RecName: Full=Hydroxycarboxylic acid receptor 1; AltName: Full=G-protein coupled receptor 104; AltName: Full=G-protein coupled receptor 81;
FUNCTION: Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.SIMILARITY: Belongs to the G-protein coupled receptor 1 family.WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gpr81/";
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
Pfam Domains: PF00001 - 7 transmembrane receptor (rhodopsin family)
ModBase Predicted Comparative 3D Structure on Q9BXC0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK122659 - Homo sapiens cDNA FLJ16094 fis, clone SPLEN2004662, moderately similar to PROBABLE G PROTEIN-COUPLED RECEPTOR HM74.AF385431 - Homo sapiens T-cell activation G protein-coupled receptor mRNA, complete cds.AF385432 - Homo sapiens T-cell activation G protein-coupled receptor splice variant 1 mRNA, complete cds.JD131935 - Sequence 112959 from Patent EP1572962.JD284863 - Sequence 265887 from Patent EP1572962.JD429021 - Sequence 410045 from Patent EP1572962.JD428003 - Sequence 409027 from Patent EP1572962.JD054745 - Sequence 35769 from Patent EP1572962.JD116090 - Sequence 97114 from Patent EP1572962.JD237047 - Sequence 218071 from Patent EP1572962.JD232132 - Sequence 213156 from Patent EP1572962.JD312270 - Sequence 293294 from Patent EP1572962.JD415031 - Sequence 396055 from Patent EP1572962.JD476819 - Sequence 457843 from Patent EP1572962.JD379780 - Sequence 360804 from Patent EP1572962.JD256593 - Sequence 237617 from Patent EP1572962.JD256592 - Sequence 237616 from Patent EP1572962.JD297326 - Sequence 278350 from Patent EP1572962.JD243281 - Sequence 224305 from Patent EP1572962.JD545838 - Sequence 526862 from Patent EP1572962.JD238453 - Sequence 219477 from Patent EP1572962.JD238454 - Sequence 219478 from Patent EP1572962.JD553896 - Sequence 534920 from Patent EP1572962.JD482075 - Sequence 463099 from Patent EP1572962.JD340927 - Sequence 321951 from Patent EP1572962.JD421935 - Sequence 402959 from Patent EP1572962.JD421936 - Sequence 402960 from Patent EP1572962.JD421938 - Sequence 402962 from Patent EP1572962.JD446395 - Sequence 427419 from Patent EP1572962.JD447862 - Sequence 428886 from Patent EP1572962.JD523472 - Sequence 504496 from Patent EP1572962.JD151882 - Sequence 132906 from Patent EP1572962.JD464927 - Sequence 445951 from Patent EP1572962.JD479023 - Sequence 460047 from Patent EP1572962.JD543528 - Sequence 524552 from Patent EP1572962.JD095806 - Sequence 76830 from Patent EP1572962.JD504630 - Sequence 485654 from Patent EP1572962.JD299927 - Sequence 280951 from Patent EP1572962.JD557242 - Sequence 538266 from Patent EP1572962.JD295627 - Sequence 276651 from Patent EP1572962.JD546799 - Sequence 527823 from Patent EP1572962.JD419100 - Sequence 400124 from Patent EP1572962.JD356132 - Sequence 337156 from Patent EP1572962.JD367112 - Sequence 348136 from Patent EP1572962.JD099280 - Sequence 80304 from Patent EP1572962.JD347323 - Sequence 328347 from Patent EP1572962.JD397157 - Sequence 378181 from Patent EP1572962.JD312391 - Sequence 293415 from Patent EP1572962.JD379789 - Sequence 360813 from Patent EP1572962.JD120613 - Sequence 101637 from Patent EP1572962.JD342337 - Sequence 323361 from Patent EP1572962.JD342336 - Sequence 323360 from Patent EP1572962.JD478128 - Sequence 459152 from Patent EP1572962.JD397882 - Sequence 378906 from Patent EP1572962.JD070238 - Sequence 51262 from Patent EP1572962.JD196433 - Sequence 177457 from Patent EP1572962.JD180965 - Sequence 161989 from Patent EP1572962.JD274636 - Sequence 255660 from Patent EP1572962.JD547115 - Sequence 528139 from Patent EP1572962.JD153507 - Sequence 134531 from Patent EP1572962.JD325983 - Sequence 307007 from Patent EP1572962.JD367273 - Sequence 348297 from Patent EP1572962.JD413669 - Sequence 394693 from Patent EP1572962.AK289557 - Homo sapiens cDNA FLJ78197 complete cds, highly similar to Homo sapiens T-cell activation G protein-coupled receptor mRNA.JD108891 - Sequence 89915 from Patent EP1572962.JD453404 - Sequence 434428 from Patent EP1572962.JD182454 - Sequence 163478 from Patent EP1572962.JD348635 - Sequence 329659 from Patent EP1572962.AF345568 - Homo sapiens putative chemokine receptor (FKSG80) mRNA, complete cds.BC066881 - Homo sapiens G protein-coupled receptor 81, mRNA (cDNA clone MGC:79318 IMAGE:6971816), complete cds.BC066882 - Homo sapiens G protein-coupled receptor 81, mRNA (cDNA clone MGC:79320 IMAGE:6971819), complete cds.BC066883 - Homo sapiens G protein-coupled receptor 81, mRNA (cDNA clone MGC:79321 IMAGE:6971820), complete cds.BC067484 - Homo sapiens G protein-coupled receptor 81, mRNA (cDNA clone MGC:79319 IMAGE:6971817), complete cds.GQ129268 - Synthetic construct Homo sapiens clone HAIB:100068568; DKFZo008C0335 G protein-coupled receptor 81 protein (GPR81) gene, complete cds.AY507143 - Homo sapiens putative chemokine receptor mRNA, complete cds.EU809458 - Homo sapiens G-protein coupled receptor 81 (GPR81) mRNA, complete cds.AK313955 - Homo sapiens cDNA, FLJ94601, Homo sapiens G protein-coupled receptor 81 (GPR81), mRNA.GQ129267 - Synthetic construct Homo sapiens clone HAIB:100068665; DKFZo004C0336 G protein-coupled receptor 81 protein (GPR81) gene, partial cds.BC095506 - Homo sapiens G protein-coupled receptor 81, mRNA (cDNA clone IMAGE:6912801), partial cds.KJ893611 - Synthetic construct Homo sapiens clone ccsbBroadEn_03005 HCAR1 gene, encodes complete protein.JD271939 - Sequence 252963 from Patent EP1572962.JD309834 - Sequence 290858 from Patent EP1572962.JD055023 - Sequence 36047 from Patent EP1572962.JD097165 - Sequence 78189 from Patent EP1572962.JD393502 - Sequence 374526 from Patent EP1572962.JD201910 - Sequence 182934 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B2R9X4, ENST00000432564.1, ENST00000432564.2, FKSG80, GPR104, GPR81, HCA1, HCAR1_HUMAN, NM_032554, Q3Y5J3, Q4VBN1, Q6NXU5, Q9BXC0, uc001ucz.1, uc001ucz.2, uc001ucz.3, uc001ucz.4, uc001ucz.5UCSC ID: ENST00000432564.3RefSeq Accession: NM_032554
Protein: Q9BXC0
(aka HCAR1_HUMAN)
CCDS: CCDS9236.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.