Human Gene RILPL2 (ENST00000280571.9) Description and Page Index
Description: Homo sapiens Rab interacting lysosomal protein like 2 (RILPL2), transcript variant 1, mRNA. (from RefSeq NM_145058) RefSeq Summary (NM_145058): This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000280571.9 Gencode Gene: ENSG00000150977.10 Transcript (Including UTRs) Position: hg38 chr12:123,410,683-123,436,717 Size: 26,035 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr12:123,415,891-123,436,420 Size: 20,530 Coding Exon Count: 4
ID:RIPL2_HUMAN DESCRIPTION: RecName: Full=RILP-like protein 2; AltName: Full=Rab-interacting lysosomal protein-like 2; AltName: Full=p40phox-binding protein; FUNCTION: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. May activate RAC1 (By similarity). SUBUNIT: Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation. Interacts with RAC1 (By similarity). INTERACTION: Self; NbExp=2; IntAct=EBI-717552, EBI-717552; SUBCELLULAR LOCATION: Cytoplasm, cytosol. TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in lung. SIMILARITY: Belongs to the RILPL family. SIMILARITY: Contains 1 RILP-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11461 - Rab interacting lysosomal protein
ModBase Predicted Comparative 3D Structure on Q969X0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.