Human Gene SNRNP35 (ENST00000526639.3) from GENCODE V44
Description: Homo sapiens small nuclear ribonucleoprotein U11/U12 subunit 35 (SNRNP35), transcript variant 2, mRNA. (from RefSeq NM_022717) RefSeq Summary (NM_022717): The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]. Gencode Transcript: ENST00000526639.3 Gencode Gene: ENSG00000184209.15 Transcript (Including UTRs) Position: hg38 chr12:123,458,139-123,466,936 Size: 8,798 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr12:123,465,541-123,466,281 Size: 741 Coding Exon Count: 1
ID:U1SBP_HUMAN DESCRIPTION: RecName: Full=U11/U12 small nuclear ribonucleoprotein 35 kDa protein; Short=U11/U12 snRNP 35 kDa protein; Short=U11/U12-35K; AltName: Full=Protein HM-1; AltName: Full=U1 snRNP-binding protein homolog; SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12- type spliceosome. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in heart, liver, skeletal muscle and pancreas. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16560
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
