Human Gene RAN (ENST00000543796.6) from GENCODE V44
Description: Homo sapiens RAN, member RAS oncogene family (RAN), transcript variant 1, mRNA. (from RefSeq NM_006325) RefSeq Summary (NM_006325): RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000543796.6 Gencode Gene: ENSG00000132341.12 Transcript (Including UTRs) Position: hg38 chr12:130,872,066-130,877,678 Size: 5,613 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr12:130,872,594-130,875,926 Size: 3,333 Coding Exon Count: 6
ID:RAN_HUMAN DESCRIPTION: RecName: Full=GTP-binding nuclear protein Ran; AltName: Full=Androgen receptor-associated protein 24; AltName: Full=GTPase Ran; AltName: Full=Ras-like protein TC4; AltName: Full=Ras-related nuclear protein; FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. FUNCTION: Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases. SUBUNIT: Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and isoform 2 of VRK2. INTERACTION: P18754:RCC1; NbExp=6; IntAct=EBI-286642, EBI-992720; Q92973:TNPO1; NbExp=2; IntAct=EBI-286642, EBI-286693; Q99986:VRK1; NbExp=12; IntAct=EBI-286642, EBI-1769146; Q86Y07-1:VRK2; NbExp=2; IntAct=EBI-286642, EBI-1207633; Q86Y07-5:VRK2; NbExp=2; IntAct=EBI-286642, EBI-1207649; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. TISSUE SPECIFICITY: Expressed in a variety of tissues. SIMILARITY: Belongs to the small GTPase superfamily. Ran family. SEQUENCE CAUTION: Sequence=BAB93486.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62826
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000055 ribosomal large subunit export from nucleus GO:0000056 ribosomal small subunit export from nucleus GO:0000060 protein import into nucleus, translocation GO:0000070 mitotic sister chromatid segregation GO:0000278 mitotic cell cycle GO:0006259 DNA metabolic process GO:0006409 tRNA export from nucleus GO:0006606 protein import into nucleus GO:0006611 protein export from nucleus GO:0006913 nucleocytoplasmic transport GO:0007049 cell cycle GO:0007052 mitotic spindle organization GO:0010586 miRNA metabolic process GO:0015031 protein transport GO:0016032 viral process GO:0030521 androgen receptor signaling pathway GO:0032092 positive regulation of protein binding GO:0035281 pre-miRNA export from nucleus GO:0045540 regulation of cholesterol biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0046039 GTP metabolic process GO:0051301 cell division GO:0061015 snRNA import into nucleus GO:0075733 intracellular transport of virus GO:1902570 protein localization to nucleolus
KJ891979 - Synthetic construct Homo sapiens clone ccsbBroadEn_01373 RAN gene, encodes complete protein. AF054183 - Homo sapiens GTP binding protein mRNA, complete cds. AK311223 - Homo sapiens cDNA, FLJ18265. AK316193 - Homo sapiens cDNA, FLJ79092 complete cds, highly similar to GTP-binding nuclear protein Ran. AK312466 - Homo sapiens cDNA, FLJ92821, Homo sapiens RAN, member RAS oncogene family (RAN), mRNA. BC000852 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone IMAGE:3458675). AK300934 - Homo sapiens cDNA FLJ52168 complete cds, highly similar to GTP-binding nuclear protein Ran. BC014518 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:10588 IMAGE:3830061), complete cds. JD377204 - Sequence 358228 from Patent EP1572962. AL357616 - Homo sapiens EST from clone 341708, 5' end. BC051908 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:60376 IMAGE:5504629), complete cds. BC072000 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:88703 IMAGE:6644326), complete cds. BC014901 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:16857 IMAGE:3910005), complete cds. BC004272 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:10827 IMAGE:3615048), complete cds. BC016654 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone MGC:17135 IMAGE:4342591), complete cds. AK290763 - Homo sapiens cDNA FLJ78394 complete cds, highly similar to Homo sapiens RAN, member RAS oncogene family (RAN), mRNA. AF052578 - Homo sapiens androgen receptor associated protein 24 (ARA24) mRNA, complete cds. AB464125 - Synthetic construct DNA, clone: pF1KB8243, Homo sapiens RAN gene for RAN, member RAS oncogene family, without stop codon, in Flexi system. CR450347 - Homo sapiens full open reading frame cDNA clone RZPDo834G022D for gene RAN, RAN, member RAS oncogene family; complete cds; without stopcodon. BT007271 - Homo sapiens RAN, member RAS oncogene family mRNA, complete cds. DQ892358 - Synthetic construct clone IMAGE:100004988; FLH185510.01X; RZPDo839B12148D RAN, member RAS oncogene family (RAN) gene, encodes complete protein. DQ895565 - Synthetic construct Homo sapiens clone IMAGE:100010025; FLH185506.01L; RZPDo839B12147D RAN, member RAS oncogene family (RAN) gene, encodes complete protein. AF501887 - Homo sapiens RAN small GTP binding protein mRNA, complete cds. M31469 - Human ras-like protein mRNA, complete cds, clone TC4. AB062399 - Homo sapiens OK/SW-cl.81 mRNA for member RAS oncogene family, complete cds. BC022813 - Homo sapiens RAN, member RAS oncogene family, mRNA (cDNA clone IMAGE:4845820). JD170898 - Sequence 151922 from Patent EP1572962. JD273432 - Sequence 254456 from Patent EP1572962. JD273783 - Sequence 254807 from Patent EP1572962. JD509745 - Sequence 490769 from Patent EP1572962. JD161151 - Sequence 142175 from Patent EP1572962. JD258085 - Sequence 239109 from Patent EP1572962. JD549392 - Sequence 530416 from Patent EP1572962. JD488858 - Sequence 469882 from Patent EP1572962. JD212094 - Sequence 193118 from Patent EP1572962. JD061872 - Sequence 42896 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ranbp2Pathway - Sumoylation by RanBP2 Regulates Transcriptional Repression h_ranPathway - Cycling of Ran in nucleocytoplasmic transport h_ranMSpathway - Role of Ran in mitotic spindle regulation h_npcPathway - Mechanism of Protein Import into the Nucleus
Reactome (by CSHL, EBI, and GO)
Protein P62826 (Reactome details) participates in the following event(s):
R-HSA-168880 vRNP Export through the nuclear pore R-HSA-180687 Conversion of Ran-GDP to Ran-GTP R-HSA-165034 Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP R-HSA-180728 Association of Ran-GTP with importin-beta R-HSA-2065539 SREBP1A,1C,2:Importin beta-1 dissociates R-HSA-6785478 Processed tRNA binds XPOT and RAN:GTP R-HSA-165055 Hydrolysis of Ran:GTP to Ran:GDP R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus R-HSA-165028 Release of the HIV mRNA and Crm1 from Rev in the cytoplasm R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC R-HSA-180736 Disassembly of the Rev-importin beta-B23:Ran-GTP complex R-HSA-203922 Exportin-5 recognizes 3' overhang of pre-miRNA R-HSA-203906 Exportin complex translocates pre-miRNA to cytosol R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm R-HSA-180739 Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-180746 Nuclear import of Rev protein R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-6784531 tRNA processing in the nucleus R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-177243 Interactions of Rev with host cellular proteins R-HSA-203927 MicroRNA (miRNA) biogenesis R-HSA-8957322 Metabolism of steroids R-HSA-72306 tRNA processing R-HSA-211000 Gene Silencing by RNA R-HSA-168255 Influenza Life Cycle R-HSA-162587 HIV Life Cycle R-HSA-162909 Host Interactions of HIV factors R-HSA-556833 Metabolism of lipids R-HSA-8953854 Metabolism of RNA R-HSA-74160 Gene expression (Transcription) R-HSA-168254 Influenza Infection R-HSA-162906 HIV Infection R-HSA-1430728 Metabolism R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
