ID:MTUS2_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated tumor suppressor candidate 2; AltName: Full=Cardiac zipper protein; AltName: Full=Microtubule plus-end tracking protein TIP150; Short=Tracking protein of 150 kDa; FUNCTION: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. SUBUNIT: Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus- end) of microtubules. TISSUE SPECIFICITY: Detected in embryonic stem cells differentiating to cardiomyocytes. SIMILARITY: In the C-terminal section; belongs to the MTUS1 family. SEQUENCE CAUTION: Sequence=AAI50246.1; Type=Erroneous initiation; Sequence=BAA34494.2; Type=Erroneous initiation; Sequence=CAI39910.1; Type=Erroneous gene model prediction; Sequence=CAI39912.1; Type=Erroneous gene model prediction; Sequence=CAI40386.1; Type=Erroneous gene model prediction; Sequence=CAI40565.1; Type=Erroneous gene model prediction; Sequence=CAI40566.1; Type=Erroneous gene model prediction; Sequence=CAI41204.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q5JR59
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
