Human Gene P2RY5 (uc001vcf.1) Description and Page Index
  Description: G-protein coupled purinergic receptor P2Y5
RefSeq Summary (NM_005767): The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009].
Transcript (Including UTRs)
   Position: hg18 chr13:47,883,183-47,916,841 Size: 33,659 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg18 chr13:47,883,526-47,884,560 Size: 1,035 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:47,883,183-47,916,841)mRNA (may differ from genome)Protein (344 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDMGIOMIMPubMedReactome
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: LPAR6_HUMAN
DESCRIPTION: RecName: Full=Lysophosphatidic acid receptor 6; Short=LPA receptor 6; Short=LPA-6; AltName: Full=Oleoyl-L-alpha-lysophosphatidic acid receptor; AltName: Full=P2Y purinoceptor 5; Short=P2Y5; AltName: Full=Purinergic receptor 5; AltName: Full=RB intron encoded G-protein coupled receptor;
FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
DEVELOPMENTAL STAGE: Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.
DISEASE: Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1) [MIM:278150]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends.
DISEASE: Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8) [MIM:278150]. A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases.
MISCELLANEOUS: This is a nested gene within intron 17 of the retinoblastoma gene.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=L11910; Type=Frameshift; Positions=31;

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -473.171625-0.291 Picture PostScript Text
3' UTR -53.53343-0.156 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002188 - P2Y5_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P43657
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0070915 lysophosphatidic acid receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035025 positive regulation of Rho protein signal transduction
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC039373 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone IMAGE:5271358).
BX647109 - Homo sapiens mRNA; cDNA DKFZp686C10196 (from clone DKFZp686C10196).
AK123059 - Homo sapiens cDNA FLJ41064 fis, clone TRACH2001021, highly similar to P2Y PURINOCEPTOR 5.
AK223389 - Homo sapiens mRNA for G-protein coupled purinergic receptor P2Y5 variant, clone: FCC107B01.
BC040850 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:49911 IMAGE:5180625), complete cds.
BX537445 - Homo sapiens mRNA; cDNA DKFZp686B1664 (from clone DKFZp686B1664); complete cds.
BX537392 - Homo sapiens mRNA; cDNA DKFZp313O1437 (from clone DKFZp313O1437); complete cds.
BX537438 - Homo sapiens mRNA; cDNA DKFZp686P1665 (from clone DKFZp686P1665); complete cds.
BC045651 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:43555 IMAGE:5269149), complete cds.
AK122856 - Homo sapiens cDNA FLJ16477 fis, clone BRSTN2013171, highly similar to P2Y purinoceptor 5.
BC070295 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:88290 IMAGE:6663864), complete cds.
BC106756 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:120358 IMAGE:40024517), complete cds.
AF000546 - Homo sapiens purinergic receptor P2Y5 mRNA, complete cds.
EU831916 - Synthetic construct Homo sapiens clone HAIB:100066945; DKFZo008B0423 purinergic receptor P2Y, G-protein coupled, 5 protein (P2RY5) gene, encodes complete protein.
EU832010 - Synthetic construct Homo sapiens clone HAIB:100067039; DKFZo004B0424 purinergic receptor P2Y, G-protein coupled, 5 protein (P2RY5) gene, encodes complete protein.
AB464111 - Synthetic construct DNA, clone: pF1KB7145, Homo sapiens P2RY5 gene for purinergic receptor P2Y, G-protein coupled, 5, without stop codon, in Flexi system.
BC054346 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone IMAGE:4479923), with apparent retained intron.
JF810890 - Homo sapiens lysophosphatidic acid receptor 6 (LPAR6) mRNA, complete cds.
HQ995530 - Homo sapiens purinergic receptor P2Y G protein-coupled protein 5 (P2RY5) mRNA, complete cds.
KJ892942 - Synthetic construct Homo sapiens clone ccsbBroadEn_02336 LPAR6 gene, encodes complete protein.
KR711837 - Synthetic construct Homo sapiens clone CCSBHm_00031289 LPAR6 (LPAR6) mRNA, encodes complete protein.
KR711838 - Synthetic construct Homo sapiens clone CCSBHm_00031291 LPAR6 (LPAR6) mRNA, encodes complete protein.
KR711839 - Synthetic construct Homo sapiens clone CCSBHm_00031294 LPAR6 (LPAR6) mRNA, encodes complete protein.
KR711840 - Synthetic construct Homo sapiens clone CCSBHm_00031297 LPAR6 (LPAR6) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P43657 (Reactome details) participates in the following event(s):

R-HSA-417890 P2Y5 receptor can bind to LPA
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-417957 P2Y receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418038 Nucleotide-like (purinergic) receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A4FTW9, BC045651, NM_005767, NP_005758, O15133, P2RY5_HUMAN, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
UCSC ID: uc001vcf.1
RefSeq Accession: NM_005767
Protein: P43657 (aka LPAR6_HUMAN)
CCDS: CCDS9410.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC045651.1
exon count: 7CDS single in 3' UTR: no RNA size: 2938
ORF size: 1035CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1362.50frame shift in genome: no % Coverage: 99.05
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.