Human Gene SLITRK5 (ENST00000325089.7) from GENCODE V44
Description: Homo sapiens SLIT and NTRK like family member 5 (SLITRK5), transcript variant 2, mRNA. (from RefSeq NM_015567) RefSeq Summary (NM_015567): Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000325089.7 Gencode Gene: ENSG00000165300.8 Transcript (Including UTRs) Position: hg38 chr13:87,672,615-87,696,272 Size: 23,658 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr13:87,675,389-87,678,265 Size: 2,877 Coding Exon Count: 1
ID:SLIK5_HUMAN DESCRIPTION: RecName: Full=SLIT and NTRK-like protein 5; AltName: Full=Leucine-rich repeat-containing protein 11; Flags: Precursor; FUNCTION: Suppresses neurite outgrowth (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable). TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. SIMILARITY: Belongs to the SLITRK family. SIMILARITY: Contains 12 LRR (leucine-rich) repeats. SIMILARITY: Contains 2 LRRCT domains. SIMILARITY: Contains 1 LRRNT domain. SEQUENCE CAUTION: Sequence=BAA74941.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94991
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
