Human Gene TGDS (ENST00000261296.7) from GENCODE V44
Description: Homo sapiens TDP-glucose 4,6-dehydratase (TGDS), transcript variant 4, non-coding RNA. (from RefSeq NR_130732) RefSeq Summary (NM_014305): The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000261296.7 Gencode Gene: ENSG00000088451.11 Transcript (Including UTRs) Position: hg38 chr13:94,574,054-94,596,152 Size: 22,099 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr13:94,574,782-94,596,136 Size: 21,355 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01370 - NAD dependent epimerase/dehydratase family
ModBase Predicted Comparative 3D Structure on O95455
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
