Human Gene UGGT2 (ENST00000376747.8) from GENCODE V44
Description: Homo sapiens UDP-glucose glycoprotein glucosyltransferase 2 (UGGT2), mRNA. (from RefSeq NM_020121) RefSeq Summary (NM_020121): UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]. Gencode Transcript: ENST00000376747.8 Gencode Gene: ENSG00000102595.22 Transcript (Including UTRs) Position: hg38 chr13:95,801,580-96,053,401 Size: 251,822 Total Exon Count: 39 Strand: - Coding Region Position: hg38 chr13:95,801,790-96,053,312 Size: 251,523 Coding Exon Count: 39
ID:UGGG2_HUMAN DESCRIPTION: RecName: Full=UDP-glucose:glycoprotein glucosyltransferase 2; Short=UGT2; Short=hUGT2; EC=2.4.1.-; AltName: Full=UDP--Glc:glycoprotein glucosyltransferase 2; AltName: Full=UDP-glucose ceramide glucosyltransferase-like 1; Flags: Precursor; FUNCTION: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). COFACTOR: Calcium or manganese. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment. TISSUE SPECIFICITY: Higher levels in kidney, pancreas, heart, and skeletal muscle. SIMILARITY: Belongs to the glycosyltransferase 8 family. CAUTION: Has no enzymatic activity towards unfolded RNase B or thyroglobulin (PubMed:10694380). WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9NYU1 (Reactome details) participates in the following event(s):
R-HSA-548884 UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b R-HSA-901032 ER Quality Control Compartment (ERQC) R-HSA-901042 Calnexin/calreticulin cycle R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
