Human Gene GPR183 (ENST00000376414.5) from GENCODE V44
Description: Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA. (from RefSeq NM_004951) RefSeq Summary (NM_004951): This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000376414.5 Gencode Gene: ENSG00000169508.7 Transcript (Including UTRs) Position: hg38 chr13:99,294,539-99,307,399 Size: 12,861 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr13:99,295,060-99,296,145 Size: 1,086 Coding Exon Count: 1
ID:GP183_HUMAN DESCRIPTION: RecName: Full=G-protein coupled receptor 183; AltName: Full=Epstein-Barr virus-induced G-protein coupled receptor 2; Short=EBI2; Short=EBV-induced G-protein coupled receptor 2; FUNCTION: Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not throughG(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. INDUCTION: By Epstein-Barr virus (EBV). MISCELLANEOUS: GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2- enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8- diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy (PubMed:21673108). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32249
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.