Human Gene TPP2 (ENST00000376065.8) from GENCODE V44
Description: Homo sapiens tripeptidyl peptidase 2 (TPP2), transcript variant 4, non-coding RNA. (from RefSeq NR_160411) RefSeq Summary (NM_003291): This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000376065.8 Gencode Gene: ENSG00000134900.13 Transcript (Including UTRs) Position: hg38 chr13:102,597,003-102,678,461 Size: 81,459 Total Exon Count: 29 Strand: + Coding Region Position: hg38 chr13:102,597,039-102,678,316 Size: 81,278 Coding Exon Count: 29
ID:TPP2_HUMAN DESCRIPTION: RecName: Full=Tripeptidyl-peptidase 2; Short=TPP-2; EC=3.4.14.10; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase II; Short=TPP-II; FUNCTION: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). CATALYTIC ACTIVITY: Release of an N-terminal tripeptide from a polypeptide. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation. MISCELLANEOUS: The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate- binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By similarity). SIMILARITY: Belongs to the peptidase S8 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00082 - Subtilase family PF12580 - Tripeptidyl peptidase II
ModBase Predicted Comparative 3D Structure on P29144
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
