ID:IPO4_HUMAN DESCRIPTION: RecName: Full=Importin-4; Short=Imp4; AltName: Full=Importin-4b; Short=Imp4b; AltName: Full=Ran-binding protein 4; Short=RanBP4; FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. SUBUNIT: Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the importin beta family. SIMILARITY: Contains 6 HEAT repeats. SIMILARITY: Contains 1 importin N-terminal domain. SEQUENCE CAUTION: Sequence=BAB15616.1; Type=Frameshift; Positions=234; Sequence=BAB55421.1; Type=Erroneous initiation; Sequence=BAC11174.1; Type=Erroneous initiation; Sequence=CAD62595.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TEX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008139 nuclear localization sequence binding GO:0008536 Ran GTPase binding GO:0008565 protein transporter activity
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0006335 DNA replication-dependent nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006607 NLS-bearing protein import into nucleus GO:0006610 ribosomal protein import into nucleus GO:0006886 intracellular protein transport GO:0015031 protein transport
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