Human Gene TSSK4 (ENST00000287913.10) from GENCODE V44
Description: Homo sapiens testis specific serine kinase 4 (TSSK4), transcript variant 2, mRNA. (from RefSeq NM_174944) RefSeq Summary (NM_174944): This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Gencode Transcript: ENST00000287913.10 Gencode Gene: ENSG00000139908.15 Transcript (Including UTRs) Position: hg38 chr14:24,205,756-24,208,248 Size: 2,493 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr14:24,205,924-24,208,146 Size: 2,223 Coding Exon Count: 4
ID:TSSK4_HUMAN DESCRIPTION: RecName: Full=Testis-specific serine/threonine-protein kinase 4; Short=TSK-4; Short=TSSK-4; Short=Testis-specific kinase 4; EC=2.7.11.1; AltName: Full=Serine/threonine-protein kinase 22E; FUNCTION: May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-197, potentially by autophosphorylation (By similarity). INTERACTION: P16220:CREB1; NbExp=5; IntAct=EBI-1202583, EBI-711855; TISSUE SPECIFICITY: Expressed only in the testis. PTM: Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6SA08
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.