Human Gene FRMD6 (ENST00000356218.8) from GENCODE V44
Description: Homo sapiens FERM domain containing 6 (FRMD6), transcript variant 1, mRNA. (from RefSeq NM_001042481)
Gencode Transcript: ENST00000356218.8
Gencode Gene: ENSG00000139926.16
Transcript (Including UTRs)
Position: hg38 chr14:51,489,137-51,730,459 Size: 241,323 Total Exon Count: 15 Strand: +
Coding Region
Position: hg38 chr14:51,689,837-51,728,029 Size: 38,193 Coding Exon Count: 13
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FRMD6_HUMAN
DESCRIPTION: RecName: Full=FERM domain-containing protein 6; AltName: Full=Willin;
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin.SIMILARITY: Contains 1 FERM domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019749 - Band_41_domain
IPR014352 - FERM/acyl-CoA-bd_prot_3-hlx
IPR019748 - FERM_central
IPR000299 - FERM_domain
IPR018979 - FERM_N
IPR018980 - FERM_PH-like_C
IPR011993 - PH_like_dom
Pfam Domains: PF09380 - FERM C-terminal PH-like domain
PF00373 - FERM central domain
PF09379 - FERM N-terminal domain
ModBase Predicted Comparative 3D Structure on Q96NE9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
JF432360 - Synthetic construct Homo sapiens clone IMAGE:100073553 FERM domain containing 6 (FRMD6) gene, encodes complete protein.KJ895372 - Synthetic construct Homo sapiens clone ccsbBroadEn_04766 FRMD6 gene, encodes complete protein.AL833158 - Homo sapiens mRNA; cDNA DKFZp686H1811 (from clone DKFZp686H1811).BX161430 - human full-length cDNA clone CS0DI008YM09 of Placenta of Homo sapiens (human).BC020521 - Homo sapiens FERM domain containing 6, mRNA (cDNA clone MGC:17921 IMAGE:3914276), complete cds.AK315764 - Homo sapiens cDNA, FLJ96877.AK055545 - Homo sapiens cDNA FLJ30983 fis, clone HHDPC2000455, weakly similar to H.sapiens PTPL1 mRNA for protein tyrosine phosphatase.BX647863 - Homo sapiens mRNA; cDNA DKFZp313A071 (from clone DKFZp313A071).JD338922 - Sequence 319946 from Patent EP1572962.JD192564 - Sequence 173588 from Patent EP1572962.CU676542 - Synthetic construct Homo sapiens gateway clone IMAGE:100020780 5' read FRMD6 mRNA.AK126521 - Homo sapiens cDNA FLJ44557 fis, clone UTERU3007913, highly similar to FERM domain-containing protein 6.LF208855 - JP 2014500723-A/16358: Polycomb-Associated Non-Coding RNAs.MA444432 - JP 2018138019-A/16358: Polycomb-Associated Non-Coding RNAs.LF323459 - JP 2014500723-A/130962: Polycomb-Associated Non-Coding RNAs.MA559036 - JP 2018138019-A/130962: Polycomb-Associated Non-Coding RNAs.LF323458 - JP 2014500723-A/130961: Polycomb-Associated Non-Coding RNAs.MA559035 - JP 2018138019-A/130961: Polycomb-Associated Non-Coding RNAs.AL833380 - Homo sapiens mRNA; cDNA DKFZp667L1914 (from clone DKFZp667L1914).AL833661 - Homo sapiens mRNA; cDNA DKFZp667E2221 (from clone DKFZp667E2221).BX648295 - Homo sapiens mRNA; cDNA DKFZp686J08125 (from clone DKFZp686J08125).BX647239 - Homo sapiens mRNA; cDNA DKFZp686M2062 (from clone DKFZp686M2062).BC029870 - Homo sapiens FERM domain containing 6, mRNA (cDNA clone IMAGE:5171067), complete cds.KJ903698 - Synthetic construct Homo sapiens clone ccsbBroadEn_13092 FRMD6 gene, encodes complete protein.CU688774 - Synthetic construct Homo sapiens gateway clone IMAGE:100016922 5' read FRMD6 mRNA.LF323457 - JP 2014500723-A/130960: Polycomb-Associated Non-Coding RNAs.MA559034 - JP 2018138019-A/130960: Polycomb-Associated Non-Coding RNAs.LF323456 - JP 2014500723-A/130959: Polycomb-Associated Non-Coding RNAs.MA559033 - JP 2018138019-A/130959: Polycomb-Associated Non-Coding RNAs.AK129995 - Homo sapiens cDNA FLJ26485 fis, clone KDN05465.JD298988 - Sequence 280012 from Patent EP1572962.JD046593 - Sequence 27617 from Patent EP1572962.LF323455 - JP 2014500723-A/130958: Polycomb-Associated Non-Coding RNAs.MA559032 - JP 2018138019-A/130958: Polycomb-Associated Non-Coding RNAs.AK021747 - Homo sapiens cDNA FLJ11685 fis, clone HEMBA1004934.LF323454 - JP 2014500723-A/130957: Polycomb-Associated Non-Coding RNAs.MA559031 - JP 2018138019-A/130957: Polycomb-Associated Non-Coding RNAs.JD318833 - Sequence 299857 from Patent EP1572962.JD109912 - Sequence 90936 from Patent EP1572962.JD309595 - Sequence 290619 from Patent EP1572962.JD354794 - Sequence 335818 from Patent EP1572962.JD495611 - Sequence 476635 from Patent EP1572962.JD086065 - Sequence 67089 from Patent EP1572962.JD283621 - Sequence 264645 from Patent EP1572962.JD277558 - Sequence 258582 from Patent EP1572962.JD233736 - Sequence 214760 from Patent EP1572962.JD404032 - Sequence 385056 from Patent EP1572962.JD167533 - Sequence 148557 from Patent EP1572962.LF323453 - JP 2014500723-A/130956: Polycomb-Associated Non-Coding RNAs.MA559030 - JP 2018138019-A/130956: Polycomb-Associated Non-Coding RNAs.JD062213 - Sequence 43237 from Patent EP1572962.JD142934 - Sequence 123958 from Patent EP1572962.JD348054 - Sequence 329078 from Patent EP1572962.LF323452 - JP 2014500723-A/130955: Polycomb-Associated Non-Coding RNAs.MA559029 - JP 2018138019-A/130955: Polycomb-Associated Non-Coding RNAs.LF323451 - JP 2014500723-A/130954: Polycomb-Associated Non-Coding RNAs.MA559028 - JP 2018138019-A/130954: Polycomb-Associated Non-Coding RNAs.JD068957 - Sequence 49981 from Patent EP1572962.JD094560 - Sequence 75584 from Patent EP1572962.JD444521 - Sequence 425545 from Patent EP1572962.JD203256 - Sequence 184280 from Patent EP1572962.JD168895 - Sequence 149919 from Patent EP1572962.JD552873 - Sequence 533897 from Patent EP1572962.JD024554 - Sequence 5578 from Patent EP1572962.JD035140 - Sequence 16164 from Patent EP1572962.JD535207 - Sequence 516231 from Patent EP1572962.JD267968 - Sequence 248992 from Patent EP1572962.JD071222 - Sequence 52246 from Patent EP1572962.JD309013 - Sequence 290037 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: C14orf31, D3DSB9, ENST00000356218.1, ENST00000356218.2, ENST00000356218.3, ENST00000356218.4, ENST00000356218.5, ENST00000356218.6, ENST00000356218.7, FRMD6_HUMAN, NM_001042481, Q5HYF2, Q8N2X1, Q8WUH7, Q96NE9, uc001wzb.1, uc001wzb.2, uc001wzb.3, uc001wzb.4, uc001wzb.5UCSC ID: ENST00000356218.8RefSeq Accession: NM_001042481
Protein: Q96NE9
(aka FRMD6_HUMAN)
CCDS: CCDS9704.1 , CCDS58318.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.