Human Gene NID2 (ENST00000216286.10) from GENCODE V44
Description: Homo sapiens nidogen 2 (NID2), mRNA. (from RefSeq NM_007361) RefSeq Summary (NM_007361): This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000216286.10 Gencode Gene: ENSG00000087303.19 Transcript (Including UTRs) Position: hg38 chr14:52,004,809-52,069,059 Size: 64,251 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr14:52,005,486-52,068,994 Size: 63,509 Coding Exon Count: 22
ID:NID2_HUMAN DESCRIPTION: RecName: Full=Nidogen-2; Short=NID-2; AltName: Full=Osteonidogen; Flags: Precursor; FUNCTION: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. SUBUNIT: Interacts with LAMA2 (By similarity). Interacts with COL13A1. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE SPECIFICITY: Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle. PTM: Highly N- and O-glycosylated. SIMILARITY: Contains 5 EGF-like domains. SIMILARITY: Contains 5 LDL-receptor class B repeats. SIMILARITY: Contains 1 NIDO domain. SIMILARITY: Contains 1 nidogen G2 beta-barrel domain. SIMILARITY: Contains 2 thyroglobulin type-1 domains. SEQUENCE CAUTION: Sequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Sequence=BAA24112.1; Type=Frameshift; Positions=54, 68, 150, 172;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14112
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.