Human Gene CHURC1 (ENST00000607599.6) from GENCODE V44
  Description: Homo sapiens churchill domain containing 1 (CHURC1), transcript variant 1, mRNA. (from RefSeq NM_145165)
Gencode Transcript: ENST00000607599.6
Gencode Gene: ENSG00000258289.10
Transcript (Including UTRs)
   Position: hg38 chr14:64,914,361-64,935,368 Size: 21,008 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr14:64,914,496-64,932,230 Size: 17,735 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:64,914,361-64,935,368)mRNA (may differ from genome)Protein (113 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CHUR_HUMAN
DESCRIPTION: RecName: Full=Protein Churchill;
FUNCTION: Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.
MASS SPECTROMETRY: Mass=13033; Method=MALDI; Range=1-112; Note=The mass difference may be explained by bound zinc ions; Source=PubMed:17610897;
SIMILARITY: Belongs to the Churchill family.
SEQUENCE CAUTION: Sequence=AAG43128.1; Type=Frameshift; Positions=92;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 44.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.30135-0.350 Picture PostScript Text
3' UTR -796.503138-0.254 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009508 - Transcrpt_activator_Churchill

Pfam Domains:
PF06573 - Churchill protein

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2JOX - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8WUH1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0045893 positive regulation of transcription, DNA-templated


-  Descriptions from all associated GenBank mRNAs
  AK303739 - Homo sapiens cDNA FLJ58825 complete cds, highly similar to Protein farnesyltransferase subunit beta (EC 2.5.1.58).
AK296850 - Homo sapiens cDNA FLJ59570 complete cds, highly similar to Protein farnesyltransferase subunit beta (EC 2.5.1.58).
LP895291 - Sequence 155 from Patent EP3253886.
JD459233 - Sequence 440257 from Patent EP1572962.
BC020550 - Homo sapiens churchill domain containing 1, mRNA (cDNA clone MGC:21406 IMAGE:4155545), complete cds.
AK315905 - Homo sapiens cDNA, FLJ78804 complete cds.
AF060510 - Homo sapiens clone 015h12 My015 protein mRNA, complete cds.
AK057626 - Homo sapiens cDNA FLJ33064 fis, clone TRACH2000079, highly similar to Churchill protein.
AK296141 - Homo sapiens cDNA FLJ51978 complete cds, moderately similar to Churchill protein.
KJ903570 - Synthetic construct Homo sapiens clone ccsbBroadEn_12964 CHURC1 gene, encodes complete protein.
JD550626 - Sequence 531650 from Patent EP1572962.
JD454443 - Sequence 435467 from Patent EP1572962.
JD204417 - Sequence 185441 from Patent EP1572962.
JD353429 - Sequence 334453 from Patent EP1572962.
JD082685 - Sequence 63709 from Patent EP1572962.
JD527997 - Sequence 509021 from Patent EP1572962.
JD512422 - Sequence 493446 from Patent EP1572962.
JD361965 - Sequence 342989 from Patent EP1572962.
JD112045 - Sequence 93069 from Patent EP1572962.
JD286357 - Sequence 267381 from Patent EP1572962.
JD208481 - Sequence 189505 from Patent EP1572962.
JD091283 - Sequence 72307 from Patent EP1572962.
JD315921 - Sequence 296945 from Patent EP1572962.
JD250570 - Sequence 231594 from Patent EP1572962.
BC010517 - Homo sapiens churchill domain containing 1, mRNA (cDNA clone IMAGE:4150580), with apparent retained intron.
JD147281 - Sequence 128305 from Patent EP1572962.
JD220326 - Sequence 201350 from Patent EP1572962.
JD196117 - Sequence 177141 from Patent EP1572962.
JD211547 - Sequence 192571 from Patent EP1572962.
JD142533 - Sequence 123557 from Patent EP1572962.
JD222877 - Sequence 203901 from Patent EP1572962.
JD222878 - Sequence 203902 from Patent EP1572962.
JD481173 - Sequence 462197 from Patent EP1572962.
JD179261 - Sequence 160285 from Patent EP1572962.
JD564302 - Sequence 545326 from Patent EP1572962.
JD558243 - Sequence 539267 from Patent EP1572962.
JD319218 - Sequence 300242 from Patent EP1572962.
JD408359 - Sequence 389383 from Patent EP1572962.
JD208820 - Sequence 189844 from Patent EP1572962.
JD208821 - Sequence 189845 from Patent EP1572962.
JD375186 - Sequence 356210 from Patent EP1572962.
JD094922 - Sequence 75946 from Patent EP1572962.
JD111878 - Sequence 92902 from Patent EP1572962.
JD111879 - Sequence 92903 from Patent EP1572962.
JD355902 - Sequence 336926 from Patent EP1572962.
JD481538 - Sequence 462562 from Patent EP1572962.
JD169530 - Sequence 150554 from Patent EP1572962.
JD438288 - Sequence 419312 from Patent EP1572962.
JD447359 - Sequence 428383 from Patent EP1572962.
JD473636 - Sequence 454660 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQ81, C14orf52, CHCH, CHUR_HUMAN, ENST00000607599.1, ENST00000607599.2, ENST00000607599.3, ENST00000607599.4, ENST00000607599.5, My015, NM_145165, Q8WUH1, Q9H3K7, uc001xhv.1, uc001xhv.2, uc001xhv.3, uc001xhv.4, uc001xhv.5
UCSC ID: ENST00000607599.6
RefSeq Accession: NM_145165
Protein: Q8WUH1 (aka CHUR_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.