Human Gene ERH (ENST00000557016.6)
  Description: Homo sapiens ERH mRNA splicing and mitosis factor (ERH), mRNA. (from RefSeq NM_004450)
Gencode Transcript: ENST00000557016.6
Gencode Gene: ENSG00000100632.11
Transcript (Including UTRs)
   Position: hg38 chr14:69,380,128-69,398,299 Size: 18,172 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr14:69,380,538-69,398,233 Size: 17,696 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:69,380,128-69,398,299)mRNA (may differ from genome)Protein (104 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Enhancer of rudimentary homolog;
FUNCTION: May have a role in the cell cycle.
SUBUNIT: Homodimer (By similarity). Interacts with POLDIP3.
TISSUE SPECIFICITY: Expressed in all tissues examined.
SIMILARITY: Belongs to the E(R) family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 130.68 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2184.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.3066-0.383 Picture PostScript Text
3' UTR -87.20410-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000781 - Enh_rudimentary

Pfam Domains:
PF01133 - Enhancer of rudimentary

Protein Data Bank (PDB) 3-D Structure
MuPIT help

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- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P84090
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding

Biological Process:
GO:0006139 nucleobase-containing compound metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0007049 cell cycle
GO:0045747 positive regulation of Notch signaling pathway

Cellular Component:
GO:0030496 midbody
GO:0034709 methylosome

-  Descriptions from all associated GenBank mRNAs
  AK130850 - Homo sapiens cDNA FLJ27340 fis, clone TST00132.
U66871 - Human enhancer of rudimentary homolog mRNA, complete cds.
BC071709 - Homo sapiens enhancer of rudimentary homolog (Drosophila), mRNA (cDNA clone MGC:87998 IMAGE:5503738), complete cds.
BC014301 - Homo sapiens enhancer of rudimentary homolog (Drosophila), mRNA (cDNA clone MGC:1509 IMAGE:3507241), complete cds.
D85758 - Homo sapiens mRNA for human protein homologous to DROER protein, complete cds.
JD081694 - Sequence 62718 from Patent EP1572962.
JD113242 - Sequence 94266 from Patent EP1572962.
JD061469 - Sequence 42493 from Patent EP1572962.
JD145820 - Sequence 126844 from Patent EP1572962.
JD137141 - Sequence 118165 from Patent EP1572962.
JD318294 - Sequence 299318 from Patent EP1572962.
KJ891121 - Synthetic construct Homo sapiens clone ccsbBroadEn_00515 ERH gene, encodes complete protein.
CR542178 - Homo sapiens full open reading frame cDNA clone RZPDo834B1124D for gene ERH, enhancer of rudimentary homolog (Drosophila); complete cds, incl. stopcodon.
AK312186 - Homo sapiens cDNA, FLJ92473, Homo sapiens enhancer of rudimentary homolog (Drosophila) (ERH),mRNA.
BT006877 - Homo sapiens enhancer of rudimentary homolog (Drosophila) mRNA, complete cds.
CR450298 - Homo sapiens full open reading frame cDNA clone RZPDo834C081D for gene ERH, enhancer of rudimentary homolog (Drosophila); complete cds; without stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5H2, ENST00000557016.1, ENST00000557016.2, ENST00000557016.3, ENST00000557016.4, ENST00000557016.5, ERH_HUMAN, NM_004450, P70659, P84090, Q14259, uc001xlc.1, uc001xlc.2, uc001xlc.3, uc001xlc.4
UCSC ID: ENST00000557016.6
RefSeq Accession: NM_004450
Protein: P84090 (aka ERH_HUMAN)
CCDS: CCDS9794.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.