Human Gene ERH (ENST00000557016.6) Description and Page Index
  Description: Homo sapiens ERH mRNA splicing and mitosis factor (ERH), mRNA. (from RefSeq NM_004450)
Gencode Transcript: ENST00000557016.6
Gencode Gene: ENSG00000100632.11
Transcript (Including UTRs)
   Position: hg38 chr14:69,380,128-69,398,299 Size: 18,172 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr14:69,380,538-69,398,233 Size: 17,696 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:69,380,128-69,398,299)mRNA (may differ from genome)Protein (104 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ERH_HUMAN
DESCRIPTION: RecName: Full=Enhancer of rudimentary homolog;
FUNCTION: May have a role in the cell cycle.
SUBUNIT: Homodimer (By similarity). Interacts with POLDIP3.
TISSUE SPECIFICITY: Expressed in all tissues examined.
SIMILARITY: Belongs to the E(R) family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 130.68 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2184.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.3066-0.383 Picture PostScript Text
3' UTR -87.20410-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000781 - Enh_rudimentary

Pfam Domains:
PF01133 - Enhancer of rudimentary

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1W9G
- X-ray MuPIT

2NML
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P84090
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding

Biological Process:
GO:0006139 nucleobase-containing compound metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0007049 cell cycle
GO:0045747 positive regulation of Notch signaling pathway

Cellular Component:
GO:0030496 midbody
GO:0034709 methylosome


-  Descriptions from all associated GenBank mRNAs
  AK130850 - Homo sapiens cDNA FLJ27340 fis, clone TST00132.
U66871 - Human enhancer of rudimentary homolog mRNA, complete cds.
BC071709 - Homo sapiens enhancer of rudimentary homolog (Drosophila), mRNA (cDNA clone MGC:87998 IMAGE:5503738), complete cds.
BC014301 - Homo sapiens enhancer of rudimentary homolog (Drosophila), mRNA (cDNA clone MGC:1509 IMAGE:3507241), complete cds.
D85758 - Homo sapiens mRNA for human protein homologous to DROER protein, complete cds.
JD081694 - Sequence 62718 from Patent EP1572962.
JD113242 - Sequence 94266 from Patent EP1572962.
JD061469 - Sequence 42493 from Patent EP1572962.
JD145820 - Sequence 126844 from Patent EP1572962.
JD137141 - Sequence 118165 from Patent EP1572962.
JD318294 - Sequence 299318 from Patent EP1572962.
KJ891121 - Synthetic construct Homo sapiens clone ccsbBroadEn_00515 ERH gene, encodes complete protein.
CR542178 - Homo sapiens full open reading frame cDNA clone RZPDo834B1124D for gene ERH, enhancer of rudimentary homolog (Drosophila); complete cds, incl. stopcodon.
AK312186 - Homo sapiens cDNA, FLJ92473, Homo sapiens enhancer of rudimentary homolog (Drosophila) (ERH),mRNA.
BT006877 - Homo sapiens enhancer of rudimentary homolog (Drosophila) mRNA, complete cds.
CR450298 - Homo sapiens full open reading frame cDNA clone RZPDo834C081D for gene ERH, enhancer of rudimentary homolog (Drosophila); complete cds; without stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5H2, ERH_HUMAN, NM_004450, P70659, P84090, Q14259, uc001xlc.1, uc001xlc.2, uc001xlc.3, uc001xlc.4
UCSC ID: uc001xlc.4
RefSeq Accession: NM_004450
Protein: P84090 (aka ERH_HUMAN)
CCDS: CCDS9794.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.