Human Gene CEP128 (ENST00000281129.7) from GENCODE V44
  Description: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mother centriole. (from UniProt Q6ZU80)
Gencode Transcript: ENST00000281129.7
Gencode Gene: ENSG00000100629.17
Transcript (Including UTRs)
   Position: hg38 chr14:80,496,474-80,939,540 Size: 443,067 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg38 chr14:80,497,479-80,916,547 Size: 419,069 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:80,496,474-80,939,540)mRNA (may differ from genome)Protein (1094 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIneXtProtPubMedUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: CE128_HUMAN
DESCRIPTION: RecName: Full=Centrosomal protein of 128 kDa;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mother centriole.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE CAUTION: Sequence=BAB71273.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.67 RPKM in Testis
Total median expression: 24.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.20171-0.288 Picture PostScript Text
3' UTR -212.201005-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026652 - CEP128

ModBase Predicted Comparative 3D Structure on Q6ZU80
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008104 protein localization

Cellular Component:
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  HQ215523 - Homo sapiens lens epithelium-derived protein (LEDP/132) mRNA, complete cds.
AK125925 - Homo sapiens cDNA FLJ43937 fis, clone TESTI4013924.
AK056756 - Homo sapiens cDNA FLJ32194 fis, clone PLACE6002419, weakly similar to TRICHOHYALIN.
BC150610 - Homo sapiens chromosome 14 open reading frame 145, mRNA (cDNA clone MGC:183520 IMAGE:9056980), complete cds.
BC036939 - Homo sapiens chromosome 14 open reading frame 145, mRNA (cDNA clone IMAGE:5402686), partial cds.
BC045834 - Homo sapiens chromosome 14 open reading frame 145, mRNA (cDNA clone IMAGE:4837483), complete cds.
JD051369 - Sequence 32393 from Patent EP1572962.
JD084899 - Sequence 65923 from Patent EP1572962.
JD247736 - Sequence 228760 from Patent EP1572962.
JD567094 - Sequence 548118 from Patent EP1572962.
JD431180 - Sequence 412204 from Patent EP1572962.
JD302016 - Sequence 283040 from Patent EP1572962.
JD551477 - Sequence 532501 from Patent EP1572962.
JD360174 - Sequence 341198 from Patent EP1572962.
JD103124 - Sequence 84148 from Patent EP1572962.
JD352156 - Sequence 333180 from Patent EP1572962.
JD182569 - Sequence 163593 from Patent EP1572962.
JD078895 - Sequence 59919 from Patent EP1572962.
JD536956 - Sequence 517980 from Patent EP1572962.
BX248746 - human full-length cDNA 5-PRIME end of clone CS0CAP003YE19 of Thymus of Homo sapiens (human).
AK309833 - Homo sapiens cDNA, FLJ99874.
DQ592805 - Homo sapiens piRNA piR-59917, complete sequence.
JD052229 - Sequence 33253 from Patent EP1572962.
JD230554 - Sequence 211578 from Patent EP1572962.
JD170024 - Sequence 151048 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B9EK52, BC150610, C14orf145, C14orf61, CE128_HUMAN, ENST00000281129.1, ENST00000281129.2, ENST00000281129.3, ENST00000281129.4, ENST00000281129.5, ENST00000281129.6, Q6ZU80, Q86X97, Q96ML4, uc001xux.1, uc001xux.2, uc001xux.3
UCSC ID: ENST00000281129.7
RefSeq Accession: NR_157142
Protein: Q6ZU80 (aka CE128_HUMAN)
CCDS: CCDS32130.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.