Human Gene FOXN3 (ENST00000557258.6) from GENCODE V44
Description: Homo sapiens forkhead box N3 (FOXN3), transcript variant 2, mRNA. (from RefSeq NM_005197) RefSeq Summary (NM_005197): This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000557258.6 Gencode Gene: ENSG00000053254.16 Transcript (Including UTRs) Position: hg38 chr14:89,156,177-89,417,233 Size: 261,057 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr14:89,162,414-89,412,476 Size: 250,063 Coding Exon Count: 5
ID:FOXN3_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein N3; AltName: Full=Checkpoint suppressor 1; FUNCTION: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). SUBUNIT: Interacts through its C-terminus with the C-terminus of SNW1/SKIP. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 fork-head DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00409
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0007095 mitotic G2 DNA damage checkpoint GO:0030154 cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0097094 craniofacial suture morphogenesis