Human Gene PPP2R5C (ENST00000334743.9) from GENCODE V44
Description: Homo sapiens protein phosphatase 2 regulatory subunit B'gamma (PPP2R5C), transcript variant 1, mRNA. (from RefSeq NM_002719) RefSeq Summary (NM_002719): The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000334743.9 Gencode Gene: ENSG00000078304.20 Transcript (Including UTRs) Position: hg38 chr14:101,809,895-101,927,977 Size: 118,083 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr14:101,809,943-101,925,272 Size: 115,330 Coding Exon Count: 14
ID:2A5G_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; AltName: Full=PP2A B subunit isoform B'-gamma; AltName: Full=PP2A B subunit isoform B56-gamma; AltName: Full=PP2A B subunit isoform PR61-gamma; AltName: Full=PP2A B subunit isoform R5-gamma; AltName: Full=Renal carcinoma antigen NY-REN-29; FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGOL1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr- 55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation. INTERACTION: O96017:CHEK2; NbExp=2; IntAct=EBI-1266173, EBI-1180783; P30153:PPP2R1A; NbExp=3; IntAct=EBI-1266170, EBI-302388; SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. TISSUE SPECIFICITY: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver. INDUCTION: Up-regulated upon DNA damage. PTM: Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56 family. SEQUENCE CAUTION: Sequence=AAC50387.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13362
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity
Biological Process: GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007165 signal transduction GO:0008285 negative regulation of cell proliferation GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043666 regulation of phosphoprotein phosphatase activity
LF384889 - JP 2014500723-A/192392: Polycomb-Associated Non-Coding RNAs. MA620466 - JP 2018138019-A/192392: Polycomb-Associated Non-Coding RNAs. AK131391 - Homo sapiens cDNA FLJ16473 fis, clone BRHIP3026052, highly similar to Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, gamma isoform. AK302470 - Homo sapiens cDNA FLJ57234 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. AK295449 - Homo sapiens cDNA FLJ57986 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. AK315072 - Homo sapiens cDNA, FLJ96026. Z69030 - H.sapiens mRNA for gamma 1 isoform of 61kDa regulatory subunit of PP2A. U37352 - Human protein phosphatase 2A B'alpha1 regulatory subunit mRNA, complete cds. BC016183 - Homo sapiens protein phosphatase 2, regulatory subunit B', gamma isoform, mRNA (cDNA clone MGC:23064 IMAGE:4855950), complete cds. CU677587 - Synthetic construct Homo sapiens gateway clone IMAGE:100017630 5' read PPP2R5C mRNA. KJ901658 - Synthetic construct Homo sapiens clone ccsbBroadEn_11052 PPP2R5C gene, encodes complete protein. AB451341 - Homo sapiens PPP2R5C mRNA for serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, partial cds, clone: FLJ03003AAAF. D26445 - Homo sapiens KIAA0044 mRNA, partial cds. L42375 - Homo sapiens protein phosphatase 2A B56-gamma1 (PP2A) mRNA, 3' end of cds. AB463199 - Synthetic construct DNA, clone: pF1KA0044, Homo sapiens PPP2R5C gene for protein phosphatase 2, regulatory subunit B', gamma isoform, without stop codon, in Flexi system. LF209656 - JP 2014500723-A/17159: Polycomb-Associated Non-Coding RNAs. MA445233 - JP 2018138019-A/17159: Polycomb-Associated Non-Coding RNAs. LF330589 - JP 2014500723-A/138092: Polycomb-Associated Non-Coding RNAs. MA566166 - JP 2018138019-A/138092: Polycomb-Associated Non-Coding RNAs. BX248254 - human full-length cDNA clone CS0DF017YJ08 of Fetal brain of Homo sapiens (human). LF209657 - JP 2014500723-A/17160: Polycomb-Associated Non-Coding RNAs. MA445234 - JP 2018138019-A/17160: Polycomb-Associated Non-Coding RNAs. LF330591 - JP 2014500723-A/138094: Polycomb-Associated Non-Coding RNAs. MA566168 - JP 2018138019-A/138094: Polycomb-Associated Non-Coding RNAs. JD083654 - Sequence 64678 from Patent EP1572962. JD555303 - Sequence 536327 from Patent EP1572962. JD232600 - Sequence 213624 from Patent EP1572962. JD142913 - Sequence 123937 from Patent EP1572962. JD207003 - Sequence 188027 from Patent EP1572962. JD263036 - Sequence 244060 from Patent EP1572962. JD219767 - Sequence 200791 from Patent EP1572962. JD224682 - Sequence 205706 from Patent EP1572962. JD149641 - Sequence 130665 from Patent EP1572962. JD160423 - Sequence 141447 from Patent EP1572962. JD092420 - Sequence 73444 from Patent EP1572962. JD563869 - Sequence 544893 from Patent EP1572962. JD458772 - Sequence 439796 from Patent EP1572962. JD537562 - Sequence 518586 from Patent EP1572962. JD375861 - Sequence 356885 from Patent EP1572962. JD432153 - Sequence 413177 from Patent EP1572962. JD171300 - Sequence 152324 from Patent EP1572962. JD091623 - Sequence 72647 from Patent EP1572962. JD488203 - Sequence 469227 from Patent EP1572962. JD423691 - Sequence 404715 from Patent EP1572962. JD371686 - Sequence 352710 from Patent EP1572962. JD398866 - Sequence 379890 from Patent EP1572962. JD204263 - Sequence 185287 from Patent EP1572962. JD302504 - Sequence 283528 from Patent EP1572962. JD346840 - Sequence 327864 from Patent EP1572962. JD296278 - Sequence 277302 from Patent EP1572962. JD420715 - Sequence 401739 from Patent EP1572962. JD333671 - Sequence 314695 from Patent EP1572962. JD274274 - Sequence 255298 from Patent EP1572962. JD436187 - Sequence 417211 from Patent EP1572962. JD109358 - Sequence 90382 from Patent EP1572962. JD091716 - Sequence 72740 from Patent EP1572962. JD126567 - Sequence 107591 from Patent EP1572962. JD345317 - Sequence 326341 from Patent EP1572962. JD224345 - Sequence 205369 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04114 - Oocyte meiosis hsa04310 - Wnt signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q13362 (Reactome details) participates in the following event(s):
R-HSA-6792871 CCNG1 recruits PP2A-PPP2R5C to MDM2 R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2 R-HSA-6811454 MAPKs phosphorylate PP2A R-HSA-6811472 IER3 recruits MAPKs to PP2A-B56-beta,gamma R-HSA-195251 Assembly of the destruction complex R-HSA-389532 PP2A binds CTLA4 homodimer R-HSA-432143 PECAM-1 binds PP2A R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 R-HSA-201685 Beta-catenin is released from the destruction complex R-HSA-388833 Phosphorylation of CTLA-4 R-HSA-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma R-HSA-5229343 AXIN is phosphorylated in the destruction complex R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex R-HSA-195275 Phosphorylation of APC component of the destruction complex R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-388809 CTLA-4 binds B7-1/B7-2 R-HSA-195304 Association of beta-catenin with the destruction complex R-HSA-390329 Dephosphorylation of AKT by PP2A R-HSA-5672957 PP2A dephosphorylates KSR1 R-HSA-5672961 PP2A dephosphorylates inactive RAFs R-HSA-5675431 PP2A dephosphorylates RAF1 R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-6804757 Regulation of TP53 Degradation R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6806003 Regulation of TP53 Expression and Degradation R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-389513 CTLA4 inhibitory signaling R-HSA-432142 Platelet sensitization by LDL R-HSA-5467337 APC truncation mutants have impaired AXIN binding R-HSA-5467340 AXIN missense mutants destabilize the destruction complex R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-199418 Negative regulation of the PI3K/AKT network R-HSA-5633007 Regulation of TP53 Activity R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-195721 Signaling by WNT R-HSA-388841 Costimulation by the CD28 family R-HSA-418346 Platelet homeostasis R-HSA-4839744 truncated APC mutants destabilize the destruction complex R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-4839748 AMER1 mutants destabilize the destruction complex R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-5673000 RAF activation R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-1257604 PIP3 activates AKT signaling R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-162582 Signal Transduction R-HSA-1280218 Adaptive Immune System R-HSA-109582 Hemostasis R-HSA-4791275 Signaling by WNT in cancer R-HSA-5673001 RAF/MAP kinase cascade R-HSA-9006925 Intracellular signaling by second messengers R-HSA-212436 Generic Transcription Pathway R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-168256 Immune System R-HSA-5663202 Diseases of signal transduction R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-73857 RNA Polymerase II Transcription R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-5683057 MAPK family signaling cascades R-HSA-74160 Gene expression (Transcription)
US Server
