Human Gene MEIS2 (uc001zjp.4) Description and Page Index
  Description: Homo sapiens Meis homeobox 2 (MEIS2), transcript variant b, mRNA.
RefSeq Summary (NM_170674): This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr15:37,183,222-37,392,341 Size: 209,120 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr15:37,186,955-37,391,667 Size: 204,713 Coding Exon Count: 12 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:37,183,222-37,392,341)mRNA (may differ from genome)Protein (394 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MEIS2
CDC HuGE Published Literature: MEIS2
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity , Body Mass Index , Eosinophils , hyperactive-impulsive symptoms , response to antipsychotic treatment , Risperidone , Waist Circumference
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    Jessica Lasky-Su et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2008, Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic. [PubMed 18821565]
  2. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  3. Eosinophils
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: MEIS2
Diseases sorted by gene-association score: cleft palate, cardiac defects, and mental retardation* (919), chromosome 15q14 deletion syndrome* (18), learning disability (7), spastic paraplegia 11, autosomal recessive (6), intellectual disability (2), cleft lip/palate (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.57 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 278.97 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -219.33674-0.325 Picture PostScript Text
3' UTR -358.781476-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00046 - Homeobox domain
PF05920 - Homeobox KN domain
PF16493 - N-terminal of Homeobox Meis and PKNOX1

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on O14770-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Descriptions from all associated GenBank mRNAs
  AF017418 - Homo sapiens homeobox protein MEIS2 (MEIS2) mRNA, partial cds.
AK226072 - Homo sapiens mRNA for homeobox protein Meis2 isoform c variant, clone: fk13183.
BC001516 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:2820 IMAGE:2964406), complete cds.
BC001844 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:4493 IMAGE:2964406), complete cds.
BC007202 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:12955 IMAGE:2964406), complete cds.
BC050431 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:54158 IMAGE:6066728), complete cds.
AF178948 - Homo sapiens TALE homeobox protein Meis2a mRNA, complete cds.
AF179896 - Homo sapiens TALE homeobox protein Meis2b mRNA, complete cds.
AF179897 - Homo sapiens TALE homeobox protein Meis2c mRNA, complete cds.
AF179898 - Homo sapiens TALE homeobox protein Meis2d mRNA, complete cds.
AF179899 - Homo sapiens TALE homeobox protein Meis2e mRNA, complete cds.
AK056038 - Homo sapiens cDNA FLJ31476 fis, clone NT2NE2001617, highly similar to HOMEOBOX PROTEIN MEIS2.
AK055936 - Homo sapiens cDNA FLJ31374 fis, clone NB9N42000430, highly similar to HOMEOBOX PROTEIN MEIS2.
AK056620 - Homo sapiens cDNA FLJ32058 fis, clone NTONG2001657, highly similar to Homo sapiens Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) (MEIS2), transcript variant h, mRNA.
AK056216 - Homo sapiens cDNA FLJ31654 fis, clone NT2RI2004230, highly similar to Homeobox protein Meis2.
AK300247 - Homo sapiens cDNA FLJ58324 complete cds, highly similar to Homeobox protein Meis2.
AK311546 - Homo sapiens cDNA, FLJ18588.
AK294411 - Homo sapiens cDNA FLJ55195 complete cds, highly similar to Homeobox protein Meis2.
KJ891604 - Synthetic construct Homo sapiens clone ccsbBroadEn_00998 MEIS2 gene, encodes complete protein.
EU446635 - Synthetic construct Homo sapiens clone IMAGE:100070192; IMAGE:100011844; FLH257292.01L Meis homeobox 2 (MEIS2) gene, encodes complete protein.
EU831824 - Synthetic construct Homo sapiens clone HAIB:100066853; DKFZo004A0122 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
KJ891605 - Synthetic construct Homo sapiens clone ccsbBroadEn_00999 MEIS2 gene, encodes complete protein.
EU831754 - Synthetic construct Homo sapiens clone HAIB:100066783; DKFZo008A0821 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
EU831831 - Synthetic construct Homo sapiens clone HAIB:100066860; DKFZo004A0822 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
AB463111 - Synthetic construct DNA, clone: pF1KB4670, Homo sapiens MEIS2 gene for Meis homeobox 2, without stop codon, in Flexi system.
CU690674 - Synthetic construct Homo sapiens gateway clone IMAGE:100021476 5' read MEIS2 mRNA.
CU674744 - Synthetic construct Homo sapiens gateway clone IMAGE:100021893 5' read MEIS2 mRNA.
AK001298 - Homo sapiens cDNA FLJ10436 fis, clone NT2RP1000574.
JD102303 - Sequence 83327 from Patent EP1572962.
JD109996 - Sequence 91020 from Patent EP1572962.
JD177113 - Sequence 158137 from Patent EP1572962.
JD284117 - Sequence 265141 from Patent EP1572962.
JD269337 - Sequence 250361 from Patent EP1572962.
JD483877 - Sequence 464901 from Patent EP1572962.
JD117853 - Sequence 98877 from Patent EP1572962.
JD306771 - Sequence 287795 from Patent EP1572962.
JD316292 - Sequence 297316 from Patent EP1572962.
JD097895 - Sequence 78919 from Patent EP1572962.
JD307260 - Sequence 288284 from Patent EP1572962.
JD114852 - Sequence 95876 from Patent EP1572962.
JD420628 - Sequence 401652 from Patent EP1572962.
JD278473 - Sequence 259497 from Patent EP1572962.
JD168633 - Sequence 149657 from Patent EP1572962.
JD344532 - Sequence 325556 from Patent EP1572962.
AY349358 - Homo sapiens unknown mRNA.
JD488969 - Sequence 469993 from Patent EP1572962.
JD452331 - Sequence 433355 from Patent EP1572962.
JD380694 - Sequence 361718 from Patent EP1572962.
JD288326 - Sequence 269350 from Patent EP1572962.
JD123132 - Sequence 104156 from Patent EP1572962.
JD043069 - Sequence 24093 from Patent EP1572962.
JD504741 - Sequence 485765 from Patent EP1572962.
JD235674 - Sequence 216698 from Patent EP1572962.
AK125465 - Homo sapiens cDNA FLJ43476 fis, clone OCBBF3000097, weakly similar to HOMEOBOX PROTEIN MEIS2.
AK094531 - Homo sapiens cDNA FLJ37212 fis, clone BRALZ2008166.
LF212909 - JP 2014500723-A/20412: Polycomb-Associated Non-Coding RNAs.
JD242235 - Sequence 223259 from Patent EP1572962.
JD519147 - Sequence 500171 from Patent EP1572962.
JD091183 - Sequence 72207 from Patent EP1572962.
JD468635 - Sequence 449659 from Patent EP1572962.
JD445051 - Sequence 426075 from Patent EP1572962.
JD178299 - Sequence 159323 from Patent EP1572962.
JD468634 - Sequence 449658 from Patent EP1572962.
JD540787 - Sequence 521811 from Patent EP1572962.
JD343892 - Sequence 324916 from Patent EP1572962.
JD340466 - Sequence 321490 from Patent EP1572962.
JD178537 - Sequence 159561 from Patent EP1572962.
JD340032 - Sequence 321056 from Patent EP1572962.
JD434765 - Sequence 415789 from Patent EP1572962.
JD043443 - Sequence 24467 from Patent EP1572962.
JD445813 - Sequence 426837 from Patent EP1572962.
JD533523 - Sequence 514547 from Patent EP1572962.
MA448486 - JP 2018138019-A/20412: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: MRG1, NM_170674, NP_002390, O14770-3, uc001zjp.3
UCSC ID: uc001zjp.4
RefSeq Accession: NM_170674
Protein: O14770-3, splice isoform of O14770 CCDS: CCDS42014.1, CCDS45217.1, CCDS45218.1, CCDS45219.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_170674.4
exon count: 13CDS single in 3' UTR: no RNA size: 3352
ORF size: 1185CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2509.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 541# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.