Human Gene VPS18 (ENST00000220509.10) from GENCODE V44
Description: Homo sapiens VPS18 core subunit of CORVET and HOPS complexes (VPS18), mRNA. (from RefSeq NM_020857) RefSeq Summary (NM_020857): Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000220509.10 Gencode Gene: ENSG00000104142.11 Transcript (Including UTRs) Position: hg38 chr15:40,894,450-40,903,975 Size: 9,526 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr15:40,894,769-40,903,341 Size: 8,573 Coding Exon Count: 5
ID:VPS18_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 18 homolog; Short=hVPS18; FUNCTION: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. SUBUNIT: Interacts with HOOK1 (By similarity). Part of a large heterooligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7. INTERACTION: Q7L1V2:MON1B; NbExp=2; IntAct=EBI-1053363, EBI-2655311; SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. TISSUE SPECIFICITY: Ubiquitous. Expression was highest in heart and low in lung. SIMILARITY: Belongs to the VPS18 family. SIMILARITY: Contains 1 clathrin repeat. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAH01513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites; Sequence=BAA95999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00637 - Region in Clathrin and VPS PF05131 - Pep3/Vps18/deep orange family
ModBase Predicted Comparative 3D Structure on Q9P253
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
