Human Gene CHAC1 (ENST00000617768.5) from GENCODE V44
Description: Homo sapiens ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1), transcript variant 1, mRNA. (from RefSeq NM_024111) RefSeq Summary (NM_024111): This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000617768.5 Gencode Gene: ENSG00000128965.13 Transcript (Including UTRs) Position: hg38 chr15:40,953,471-40,956,512 Size: 3,042 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr15:40,953,584-40,955,774 Size: 2,191 Coding Exon Count: 3
ID:CHAC1_HUMAN DESCRIPTION: RecName: Full=Cation transport regulator-like protein 1; AltName: Full=Blocks Notch protein; Short=Botch; FUNCTION: Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. SUBUNIT: Interacts with NOTCH1 (via extracellular region) (By similarity). INTERACTION: Q9BQY4:RHOXF2; NbExp=2; IntAct=EBI-751127, EBI-372094; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network (By similarity). Cytoplasm, cytosol. INDUCTION: Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin. SIMILARITY: Belongs to the chaC family. CAUTION: It is uncertain whether Met-1 or Met-43 is the initiator. Met-1 is not conserved in orthologs. SEQUENCE CAUTION: Sequence=AAH01683.1; Type=Erroneous initiation; Sequence=AAH01847.1; Type=Erroneous initiation; Sequence=AAH19625.1; Type=Erroneous initiation; Sequence=AAW23972.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BUX1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006750 glutathione biosynthetic process GO:0006751 glutathione catabolic process GO:0006915 apoptotic process GO:0006986 response to unfolded protein GO:0007219 Notch signaling pathway GO:0007399 nervous system development GO:0010955 negative regulation of protein processing GO:0022008 neurogenesis GO:0045746 negative regulation of Notch signaling pathway GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress