Human Gene EHD4 (ENST00000220325.9) from GENCODE V44
Description: Homo sapiens EH domain containing 4 (EHD4), mRNA. (from RefSeq NM_139265)
Gencode Transcript: ENST00000220325.9
Gencode Gene: ENSG00000103966.11
Transcript (Including UTRs)
Position: hg38 chr15:41,895,933-41,972,557 Size: 76,625 Total Exon Count: 6 Strand: -
Coding Region
Position: hg38 chr15:41,900,645-41,972,494 Size: 71,850 Coding Exon Count: 6
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: EHD4_HUMAN
DESCRIPTION: RecName: Full=EH domain-containing protein 4; AltName: Full=Hepatocellular carcinoma-associated protein 10/11; AltName: Full=PAST homolog 4;
FUNCTION: Plays a role in early endosomal transport.SUBUNIT: Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3.SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Highly expressed in pancreas and heart.DOMAIN: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity).SIMILARITY: Contains 1 EF-hand domain.SIMILARITY: Contains 1 EH domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001401 - Dynamin_GTPase
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR000261 - EPS15_homology
Pfam Domains: PF00350 - Dynamin family
ModBase Predicted Comparative 3D Structure on Q9H223
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF205850 - JP 2014500723-A/13353: Polycomb-Associated Non-Coding RNAs.MA441427 - JP 2018138019-A/13353: Polycomb-Associated Non-Coding RNAs.BC077716 - Homo sapiens cDNA clone IMAGE:5020413, containing frame-shift errors.AF454953 - Homo sapiens EH domain-containing protein-4 mRNA, complete cds.BC006287 - Homo sapiens EH-domain containing 4, mRNA (cDNA clone MGC:10536 IMAGE:3958645), complete cds.BC051823 - Homo sapiens EH-domain containing 4, mRNA (cDNA clone MGC:60080 IMAGE:4944876), complete cds.AK024902 - Homo sapiens cDNA: FLJ21249 fis, clone COL01244, highly similar to AF181265 Homo sapiens EH domain containing 4 (EHD4) mRNA.AF181265 - Homo sapiens EH domain containing 4 (EHD4) mRNA, partial cds.AF323924 - Homo sapiens hepatocellular carcinoma-associated protein HCA11 mRNA, complete cds.AF307137 - Homo sapiens EH domain-containing protein FKSG7 (FKSG7) mRNA, complete cds.AK292634 - Homo sapiens cDNA FLJ77391 complete cds, highly similar to Homo sapiens EH-domain containing 4 (EHD4), mRNA.KJ906140 - Synthetic construct Homo sapiens clone ccsbBroadEn_15810 EHD4 gene, encodes complete protein.DQ892745 - Synthetic construct clone IMAGE:100005375; FLH189305.01X; RZPDo839D0974D EH-domain containing 4 (EHD4) gene, encodes complete protein.DQ895991 - Synthetic construct Homo sapiens clone IMAGE:100010451; FLH189301.01L; RZPDo839D0964D EH-domain containing 4 (EHD4) gene, encodes complete protein.CU690850 - Synthetic construct Homo sapiens gateway clone IMAGE:100021441 5' read EHD4 mRNA.AK074621 - Homo sapiens cDNA FLJ90140 fis, clone HEMBB1001048.AL137436 - Homo sapiens mRNA; cDNA DKFZp761H0824 (from clone DKFZp761H0824).JD264725 - Sequence 245749 from Patent EP1572962.JD415668 - Sequence 396692 from Patent EP1572962.JD499756 - Sequence 480780 from Patent EP1572962.LF348863 - JP 2014500723-A/156366: Polycomb-Associated Non-Coding RNAs.MA584440 - JP 2018138019-A/156366: Polycomb-Associated Non-Coding RNAs.AF086163 - Homo sapiens full length insert cDNA clone ZB78B06.JD062250 - Sequence 43274 from Patent EP1572962.JD243750 - Sequence 224774 from Patent EP1572962.JD042301 - Sequence 23325 from Patent EP1572962.JD411312 - Sequence 392336 from Patent EP1572962.JD269078 - Sequence 250102 from Patent EP1572962.JD564989 - Sequence 546013 from Patent EP1572962.JD244355 - Sequence 225379 from Patent EP1572962.JD104707 - Sequence 85731 from Patent EP1572962.JD206978 - Sequence 188002 from Patent EP1572962.JD368258 - Sequence 349282 from Patent EP1572962.JD534974 - Sequence 515998 from Patent EP1572962.JD545342 - Sequence 526366 from Patent EP1572962.JD438053 - Sequence 419077 from Patent EP1572962.JD330646 - Sequence 311670 from Patent EP1572962.LF348864 - JP 2014500723-A/156367: Polycomb-Associated Non-Coding RNAs.MA584441 - JP 2018138019-A/156367: Polycomb-Associated Non-Coding RNAs.JD078219 - Sequence 59243 from Patent EP1572962.JD212544 - Sequence 193568 from Patent EP1572962.JD493140 - Sequence 474164 from Patent EP1572962.LF348865 - JP 2014500723-A/156368: Polycomb-Associated Non-Coding RNAs.MA584442 - JP 2018138019-A/156368: Polycomb-Associated Non-Coding RNAs.JD474140 - Sequence 455164 from Patent EP1572962.JD044706 - Sequence 25730 from Patent EP1572962.JD218938 - Sequence 199962 from Patent EP1572962.LF348866 - JP 2014500723-A/156369: Polycomb-Associated Non-Coding RNAs.MA584443 - JP 2018138019-A/156369: Polycomb-Associated Non-Coding RNAs.LF348867 - JP 2014500723-A/156370: Polycomb-Associated Non-Coding RNAs.MA584444 - JP 2018138019-A/156370: Polycomb-Associated Non-Coding RNAs.LF348873 - JP 2014500723-A/156376: Polycomb-Associated Non-Coding RNAs.MA584450 - JP 2018138019-A/156376: Polycomb-Associated Non-Coding RNAs.LF348877 - JP 2014500723-A/156380: Polycomb-Associated Non-Coding RNAs.MA584454 - JP 2018138019-A/156380: Polycomb-Associated Non-Coding RNAs.JD204150 - Sequence 185174 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis
Other Names for This Gene
Alternate Gene Symbols: EHD4_HUMAN, ENST00000220325.1, ENST00000220325.2, ENST00000220325.3, ENST00000220325.4, ENST00000220325.5, ENST00000220325.6, ENST00000220325.7, ENST00000220325.8, FKSG7, HCA10, HCA11, NM_139265, PAST4, Q9H223, Q9HAR1, Q9NZN2, uc001zot.1, uc001zot.2, uc001zot.3, uc001zot.4, uc001zot.5UCSC ID: ENST00000220325.9RefSeq Accession: NM_139265
Protein: Q9H223
(aka EHD4_HUMAN)
CCDS: CCDS10081.1
Methods, Credits, and Use Restrictions
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