ID:ELL3_HUMAN DESCRIPTION: RecName: Full=RNA polymerase II elongation factor ELL3; FUNCTION: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis specific. SIMILARITY: Belongs to the ELL/occludin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HB65
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006354 DNA-templated transcription, elongation GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0007283 spermatogenesis GO:0010717 regulation of epithelial to mesenchymal transition GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048863 stem cell differentiation GO:0050769 positive regulation of neurogenesis GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:2000179 positive regulation of neural precursor cell proliferation