Human Gene FRMD5 (ENST00000417257.6) from GENCODE V44
Description: Homo sapiens FERM domain containing 5 (FRMD5), transcript variant 2, mRNA. (from RefSeq NM_032892)
Gencode Transcript: ENST00000417257.6
Gencode Gene: ENSG00000171877.21
Transcript (Including UTRs)
Position: hg38 chr15:43,870,764-44,195,271 Size: 324,508 Total Exon Count: 14 Strand: -
Coding Region
Position: hg38 chr15:43,873,885-44,195,054 Size: 321,170 Coding Exon Count: 14
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FRMD5_HUMAN
DESCRIPTION: RecName: Full=FERM domain-containing protein 5;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).SIMILARITY: Contains 1 FERM domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019749 - Band_41_domain
IPR019750 - Band_41_fam
IPR000798 - Ez/rad/moesin
IPR014847 - FERM-adjacent
IPR014352 - FERM/acyl-CoA-bd_prot_3-hlx
IPR019748 - FERM_central
IPR019747 - FERM_CS
IPR000299 - FERM_domain
IPR018979 - FERM_N
IPR018980 - FERM_PH-like_C
IPR011993 - PH_like_dom
Pfam Domains: PF08736 - FERM adjacent (FA)
PF09380 - FERM C-terminal PH-like domain
PF00373 - FERM central domain
PF09379 - FERM N-terminal domain
ModBase Predicted Comparative 3D Structure on Q7Z6J6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC043486 - Homo sapiens FERM domain containing 5, mRNA (cDNA clone IMAGE:5548668).BC007796 - Homo sapiens cDNA clone IMAGE:4111078, containing frame-shift errors.AK123018 - Homo sapiens cDNA FLJ41022 fis, clone ASTRO1000009, highly similar to FERM domain-containing protein 5.AK090572 - Homo sapiens cDNA FLJ33253 fis, clone ASTRO2005343, weakly similar to BAND 4.1-LIKE PROTEIN 4.AX746516 - Sequence 41 from Patent EP1308459.BC053647 - Homo sapiens FERM domain containing 5, mRNA (cDNA clone MGC:61436 IMAGE:5578205), complete cds.KJ895066 - Synthetic construct Homo sapiens clone ccsbBroadEn_04460 FRMD5 gene, encodes complete protein.CU691018 - Synthetic construct Homo sapiens gateway clone IMAGE:100021744 5' read FRMD5 mRNA.BC020191 - Homo sapiens FERM domain containing 5, mRNA (cDNA clone IMAGE:4844595), containing frame-shift errors.DQ570824 - Homo sapiens piRNA piR-30936, complete sequence.JD248598 - Sequence 229622 from Patent EP1572962.JD324606 - Sequence 305630 from Patent EP1572962.JD500184 - Sequence 481208 from Patent EP1572962.JD133269 - Sequence 114293 from Patent EP1572962.AK290013 - Homo sapiens cDNA FLJ75251 complete cds.JD153729 - Sequence 134753 from Patent EP1572962.JD079335 - Sequence 60359 from Patent EP1572962.JD304016 - Sequence 285040 from Patent EP1572962.JD148161 - Sequence 129185 from Patent EP1572962.JD520277 - Sequence 501301 from Patent EP1572962.JD226826 - Sequence 207850 from Patent EP1572962.JD240457 - Sequence 221481 from Patent EP1572962.JD200099 - Sequence 181123 from Patent EP1572962.JD372426 - Sequence 353450 from Patent EP1572962.JD111057 - Sequence 92081 from Patent EP1572962.JD040425 - Sequence 21449 from Patent EP1572962.JD382908 - Sequence 363932 from Patent EP1572962.JD563841 - Sequence 544865 from Patent EP1572962.JD085861 - Sequence 66885 from Patent EP1572962.JD137155 - Sequence 118179 from Patent EP1572962.JD384882 - Sequence 365906 from Patent EP1572962.JD292055 - Sequence 273079 from Patent EP1572962.JD177236 - Sequence 158260 from Patent EP1572962.JD129075 - Sequence 110099 from Patent EP1572962.JD257332 - Sequence 238356 from Patent EP1572962.JD106292 - Sequence 87316 from Patent EP1572962.JD138840 - Sequence 119864 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000417257.1, ENST00000417257.2, ENST00000417257.3, ENST00000417257.4, ENST00000417257.5, FRMD5_HUMAN, NM_032892, Q7Z6J6, Q8NBG4, uc001ztl.1, uc001ztl.2, uc001ztl.3, uc001ztl.4, uc001ztl.5, uc001ztl.6UCSC ID: ENST00000417257.6RefSeq Accession: NM_032892
Protein: Q7Z6J6
(aka FRMD5_HUMAN)
CCDS: CCDS10107.2
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.