Human Gene GABPB1 (ENST00000380877.8) from GENCODE V44
Description: Homo sapiens GA binding protein transcription factor subunit beta 1 (GABPB1), transcript variant beta-2, mRNA. (from RefSeq NM_016654) RefSeq Summary (NM_016654): This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000380877.8 Gencode Gene: ENSG00000104064.18 Transcript (Including UTRs) Position: hg38 chr15:50,275,389-50,355,198 Size: 79,810 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr15:50,278,632-50,309,798 Size: 31,167 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q06547
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007005 mitochondrion organization GO:0045944 positive regulation of transcription from RNA polymerase II promoter
US Server
