Human Gene GNB5 (ENST00000358784.11) from GENCODE V44
Description: Homo sapiens G protein subunit beta 5 (GNB5), transcript variant 1, mRNA. (from RefSeq NM_006578) RefSeq Summary (NM_006578): Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000358784.11 Gencode Gene: ENSG00000069966.19 Transcript (Including UTRs) Position: hg38 chr15:52,122,206-52,180,001 Size: 57,796 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr15:52,122,757-52,179,879 Size: 57,123 Coding Exon Count: 11
ID:GBB5_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit beta-5; AltName: Full=Gbeta5; AltName: Full=Transducin beta chain 5; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity). TISSUE SPECIFICITY: Expressed in multiple tissues. SIMILARITY: Belongs to the WD repeat G protein beta family. SIMILARITY: Contains 7 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14775
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.