Human Gene ALDH1A2 (ENST00000559517.5) from GENCODE V44
Description: Homo sapiens aldehyde dehydrogenase 1 family member A2 (ALDH1A2), transcript variant 3, mRNA. (from RefSeq NM_170697) RefSeq Summary (NM_170697): This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000559517.5 Gencode Gene: ENSG00000128918.15 Transcript (Including UTRs) Position: hg38 chr15:57,955,167-58,014,101 Size: 58,935 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr15:57,955,197-58,013,932 Size: 58,736 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00171 - Aldehyde dehydrogenase family
ModBase Predicted Comparative 3D Structure on O94788
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001758 retinal dehydrogenase activity GO:0004028 3-chloroallyl aldehyde dehydrogenase activity GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016918 retinal binding
Biological Process: GO:0001568 blood vessel development GO:0001822 kidney development GO:0001889 liver development GO:0001936 regulation of endothelial cell proliferation GO:0002138 retinoic acid biosynthetic process GO:0003007 heart morphogenesis GO:0006776 vitamin A metabolic process GO:0007494 midgut development GO:0008152 metabolic process GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009855 determination of bilateral symmetry GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0010628 positive regulation of gene expression GO:0014032 neural crest cell development GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0021983 pituitary gland development GO:0030182 neuron differentiation GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031016 pancreas development GO:0031076 embryonic camera-type eye development GO:0032355 response to estradiol GO:0033189 response to vitamin A GO:0034097 response to cytokine GO:0035115 embryonic forelimb morphogenesis GO:0035799 ureter maturation GO:0042572 retinol metabolic process GO:0042573 retinoic acid metabolic process GO:0042574 retinal metabolic process GO:0042904 9-cis-retinoic acid biosynthetic process GO:0043010 camera-type eye development GO:0043065 positive regulation of apoptotic process GO:0048384 retinoic acid receptor signaling pathway GO:0048566 embryonic digestive tract development GO:0048738 cardiac muscle tissue development GO:0055114 oxidation-reduction process GO:0060324 face development GO:0071300 cellular response to retinoic acid GO:0090242 retinoic acid receptor signaling pathway involved in somitogenesis
US Server
