Human Gene DENND4A (ENST00000431932.6) from GENCODE V44
Description: Homo sapiens DENN domain containing 4A (DENND4A), transcript variant 2, mRNA. (from RefSeq NM_005848) RefSeq Summary (NM_005848): This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000431932.6 Gencode Gene: ENSG00000174485.16 Transcript (Including UTRs) Position: hg38 chr15:65,661,777-65,792,124 Size: 130,348 Total Exon Count: 32 Strand: - Coding Region Position: hg38 chr15:65,661,851-65,756,450 Size: 94,600 Coding Exon Count: 30
ID:MYCPP_HUMAN DESCRIPTION: RecName: Full=C-myc promoter-binding protein; AltName: Full=DENN domain-containing protein 4A; FUNCTION: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. DEVELOPMENTAL STAGE: Highly expressed in fetal liver. INDUCTION: By serum in low-passage fibroblasts. SIMILARITY: Contains 1 dDENN domain. SIMILARITY: Contains 1 DENN domain. SIMILARITY: Contains 1 MABP domain. SIMILARITY: Contains 2 PPR (pentatricopeptide) repeats. SIMILARITY: Contains 1 uDENN domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z401
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.