Human Gene IQGAP1 (ENST00000268182.10) from GENCODE V44
Description: Homo sapiens IQ motif containing GTPase activating protein 1 (IQGAP1), mRNA. (from RefSeq NM_003870) RefSeq Summary (NM_003870): This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000268182.10 Gencode Gene: ENSG00000140575.13 Transcript (Including UTRs) Position: hg38 chr15:90,388,242-90,502,239 Size: 113,998 Total Exon Count: 38 Strand: + Coding Region Position: hg38 chr15:90,388,342-90,500,108 Size: 111,767 Coding Exon Count: 38
ID:IQGA1_HUMAN DESCRIPTION: RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195; FUNCTION: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. SUBUNIT: Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. INTERACTION: P60953:CDC42; NbExp=2; IntAct=EBI-297509, EBI-81752; P00533:EGFR; NbExp=4; IntAct=EBI-297509, EBI-297353; P04626:ERBB2; NbExp=5; IntAct=EBI-297509, EBI-641062; SUBCELLULAR LOCATION: Cell membrane. TISSUE SPECIFICITY: Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. DOMAIN: Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2. PTM: Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser- 1443 phosphorylation enhances the ability to promote neurite outgrowth. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 4 IQ domains. SIMILARITY: Contains 1 Ras-GAP domain. SIMILARITY: Contains 1 WW domain. SEQUENCE CAUTION: Sequence=BAA06123.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P46940
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
