ID:SO3A1_HUMAN DESCRIPTION: RecName: Full=Solute carrier organic anion transporter family member 3A1; Short=OATP3A1; AltName: Full=Organic anion transporter polypeptide-related protein 3; Short=OATP-RP3; Short=OATPRP3; AltName: Full=Organic anion-transporting polypeptide D; Short=OATP-D; AltName: Full=PGE1 transporter; AltName: Full=Sodium-independent organic anion transporter D; AltName: Full=Solute carrier family 21 member 11; FUNCTION: Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=101 nM for PGE1 (isoform 1); KM=218 nM for PGE1 (isoform 2); KM=219 nM for PGE2 (isoform 1); KM=371 nM for PGE2 (isoform 2); SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family. SIMILARITY: Contains 1 Kazal-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UIG8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0015732 prostaglandin transport GO:0043252 sodium-independent organic anion transport GO:0055085 transmembrane transport
AB031050 - Homo sapiens mRNA for organic anion transporter OATP-D, complete cds. AF205074 - Homo sapiens organic anion transporter polypeptide-related protein 3 (OATPRP3) mRNA, complete cds. BC000585 - Homo sapiens solute carrier organic anion transporter family, member 3A1, mRNA (cDNA clone MGC:659 IMAGE:3163826), complete cds. AK290872 - Homo sapiens cDNA FLJ76155 complete cds, highly similar to Homo sapiens solute carrier organic anion transporter family, member 3A1 (SLCO3A1), mRNA. CU674284 - Synthetic construct Homo sapiens gateway clone IMAGE:100020022 5' read SLCO3A1 mRNA. AF187816 - Homo sapiens PGE1 transporter mRNA, complete cds. DQ891954 - Synthetic construct clone IMAGE:100004584; FLH181733.01X; RZPDo839G07136D solute carrier organic anion transporter family, member 3A1 (SLCO3A1) gene, encodes complete protein. DQ895140 - Synthetic construct Homo sapiens clone IMAGE:100009600; FLH181729.01L; RZPDo839G07135D solute carrier organic anion transporter family, member 3A1 (SLCO3A1) gene, encodes complete protein. KJ898697 - Synthetic construct Homo sapiens clone ccsbBroadEn_08091 SLCO3A1 gene, encodes complete protein. AK097797 - Homo sapiens cDNA FLJ40478 fis, clone TESTI2043277, highly similar to Solute carrier organic anion transporter family member 3A1. AK310306 - Homo sapiens cDNA, FLJ17348. AK308463 - Homo sapiens cDNA, FLJ98504. AK057031 - Homo sapiens cDNA FLJ32469 fis, clone SKNMC2000256, highly similar to Solute carrier organic anion transporter family member 3A1. LF212117 - JP 2014500723-A/19620: Polycomb-Associated Non-Coding RNAs. MA447694 - JP 2018138019-A/19620: Polycomb-Associated Non-Coding RNAs. LF213089 - JP 2014500723-A/20592: Polycomb-Associated Non-Coding RNAs. MA448666 - JP 2018138019-A/20592: Polycomb-Associated Non-Coding RNAs. JD462688 - Sequence 443712 from Patent EP1572962. JD478051 - Sequence 459075 from Patent EP1572962. JD458185 - Sequence 439209 from Patent EP1572962. JD094910 - Sequence 75934 from Patent EP1572962. JD335227 - Sequence 316251 from Patent EP1572962. JD054705 - Sequence 35729 from Patent EP1572962. AK124270 - Homo sapiens cDNA FLJ42276 fis, clone TLIVE2001927. JD509889 - Sequence 490913 from Patent EP1572962. JD097166 - Sequence 78190 from Patent EP1572962. JD056094 - Sequence 37118 from Patent EP1572962. JD334596 - Sequence 315620 from Patent EP1572962. JD214357 - Sequence 195381 from Patent EP1572962. JD203238 - Sequence 184262 from Patent EP1572962. JD526648 - Sequence 507672 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UIG8 (Reactome details) participates in the following event(s):
R-HSA-879584 SLCO3A1 isoform 1 has abroad substrate specificity R-HSA-879518 Transport of organic anions R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
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