Human Gene HMOX2 (ENST00000570646.6) from GENCODE V44
Description: Homo sapiens heme oxygenase 2 (HMOX2), transcript variant 3, mRNA. (from RefSeq NM_002134) RefSeq Summary (NM_002134): Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]. Gencode Transcript: ENST00000570646.6 Gencode Gene: ENSG00000103415.12 Transcript (Including UTRs) Position: hg38 chr16:4,476,398-4,510,347 Size: 33,950 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr16:4,505,525-4,509,756 Size: 4,232 Coding Exon Count: 5
ID:HMOX2_HUMAN DESCRIPTION: RecName: Full=Heme oxygenase 2; Short=HO-2; EC=1.14.99.3; FUNCTION: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. CATALYTIC ACTIVITY: Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O. SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum. INDUCTION: Heme oxygenase 2 activity is non-inducible. SIMILARITY: Belongs to the heme oxygenase family. SIMILARITY: Contains 2 HRM (heme regulatory motif) repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hmox2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30519
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.