Human Gene UBN1 (ENST00000262376.11) from GENCODE V44
Description: Homo sapiens ubinuclein 1 (UBN1), transcript variant 2, mRNA. (from RefSeq NM_001079514) RefSeq Summary (NM_001079514): Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]. Gencode Transcript: ENST00000262376.11 Gencode Gene: ENSG00000118900.15 Transcript (Including UTRs) Position: hg38 chr16:4,847,481-4,882,401 Size: 34,921 Total Exon Count: 18 Strand: + Coding Region Position: hg38 chr16:4,852,918-4,880,132 Size: 27,215 Coding Exon Count: 17
ID:UBN1_HUMAN DESCRIPTION: RecName: Full=Ubinuclein-1; AltName: Full=HIRA-binding protein; AltName: Full=Protein VT4; AltName: Full=Ubiquitously expressed nuclear protein; FUNCTION: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. SUBUNIT: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis. TISSUE SPECIFICITY: Ubiquitous. Also expressed in numerous tumors and cancer cell lines. SIMILARITY: Belongs to the ubinuclein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NPG3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0006325 chromatin organization GO:0006336 DNA replication-independent nucleosome assembly GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0016032 viral process
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