Human Gene PRM1 (ENST00000312511.4) from GENCODE V44
  Description: Homo sapiens protamine 1 (PRM1), mRNA. (from RefSeq NM_002761)
Gencode Transcript: ENST00000312511.4
Gencode Gene: ENSG00000175646.4
Transcript (Including UTRs)
   Position: hg38 chr16:11,280,841-11,281,330 Size: 490 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr16:11,280,992-11,281,238 Size: 247 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:11,280,841-11,281,330)mRNA (may differ from genome)Protein (51 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q3MN80_HUMAN
DESCRIPTION: RecName: Full=Sperm protamine P1;
FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the protamine P1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PRM1
Diseases sorted by gene-association score: male infertility (13), pelvic varices (9), male reproductive system disease (7), reproductive system disease (4), infertility (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9670.53 RPKM in Testis
Total median expression: 9686.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.1092-0.316 Picture PostScript Text
3' UTR -20.10151-0.133 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000221 - Protamine_P1

Pfam Domains:
PF00260 - Protamine P1

ModBase Predicted Comparative 3D Structure on Q3MN80
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0030261 chromosome condensation

Cellular Component:
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome


-  Descriptions from all associated GenBank mRNAs
  HM005404 - Homo sapiens clone HTL-T-91 testicular tissue protein Li 91 mRNA, complete cds.
AY651260 - Homo sapiens testis specific protamine 1 (P1) mRNA, complete cds.
JD406485 - Sequence 387509 from Patent EP1572962.
JD129342 - Sequence 110366 from Patent EP1572962.
JD354272 - Sequence 335296 from Patent EP1572962.
Y00443 - Human testis specific mRNA for protamine 1 (P1).
BC003673 - Homo sapiens protamine 1, mRNA (cDNA clone MGC:12307 IMAGE:3935638), complete cds.
JD470704 - Sequence 451728 from Patent EP1572962.
JD174946 - Sequence 155970 from Patent EP1572962.
JD313660 - Sequence 294684 from Patent EP1572962.
AK311987 - Homo sapiens cDNA, FLJ92260, Homo sapiens protamine 1 (PRM1), mRNA.
BT006746 - Homo sapiens protamine 1 mRNA, complete cds.
KJ897382 - Synthetic construct Homo sapiens clone ccsbBroadEn_06776 PRM1 gene, encodes complete protein.
KR710164 - Synthetic construct Homo sapiens clone CCSBHm_00010178 PRM1 (PRM1) mRNA, encodes complete protein.
KR710165 - Synthetic construct Homo sapiens clone CCSBHm_00010179 PRM1 (PRM1) mRNA, encodes complete protein.
DQ892487 - Synthetic construct clone IMAGE:100005117; FLH186753.01X; RZPDo839A0272D protamine 1 (PRM1) gene, encodes complete protein.
DQ895698 - Synthetic construct Homo sapiens clone IMAGE:100010158; FLH186749.01L; RZPDo839A0262D protamine 1 (PRM1) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000312511.1, ENST00000312511.2, ENST00000312511.3, hCG_15067, NM_002761, P1, Q3MN80, Q3MN80_HUMAN, uc002dav.1, uc002dav.2, uc002dav.3, uc002dav.4, uc002dav.5
UCSC ID: ENST00000312511.4
RefSeq Accession: NM_002761
Protein: Q3MN80 CCDS: CCDS10547.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.