Human Gene PRM1 (ENST00000312511.4) from GENCODE V44
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: Q3MN80_HUMAN
DESCRIPTION: RecName: Full=Sperm protamine P1;
FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the protamine P1 family.
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Primer design for this transcript
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR000221 - Protamine_P1
Pfam Domains: PF00260 - Protamine P1
ModBase Predicted Comparative 3D Structure on Q3MN80
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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HM005404 - Homo sapiens clone HTL-T-91 testicular tissue protein Li 91 mRNA, complete cds. AY651260 - Homo sapiens testis specific protamine 1 (P1) mRNA, complete cds. JD406485 - Sequence 387509 from Patent EP1572962. JD129342 - Sequence 110366 from Patent EP1572962. JD354272 - Sequence 335296 from Patent EP1572962. Y00443 - Human testis specific mRNA for protamine 1 (P1). BC003673 - Homo sapiens protamine 1, mRNA (cDNA clone MGC:12307 IMAGE:3935638), complete cds. JD470704 - Sequence 451728 from Patent EP1572962. JD174946 - Sequence 155970 from Patent EP1572962. JD313660 - Sequence 294684 from Patent EP1572962. AK311987 - Homo sapiens cDNA, FLJ92260, Homo sapiens protamine 1 (PRM1), mRNA. BT006746 - Homo sapiens protamine 1 mRNA, complete cds. KJ897382 - Synthetic construct Homo sapiens clone ccsbBroadEn_06776 PRM1 gene, encodes complete protein. KR710164 - Synthetic construct Homo sapiens clone CCSBHm_00010178 PRM1 (PRM1) mRNA, encodes complete protein. KR710165 - Synthetic construct Homo sapiens clone CCSBHm_00010179 PRM1 (PRM1) mRNA, encodes complete protein. DQ892487 - Synthetic construct clone IMAGE:100005117; FLH186753.01X; RZPDo839A0272D protamine 1 (PRM1) gene, encodes complete protein. DQ895698 - Synthetic construct Homo sapiens clone IMAGE:100010158; FLH186749.01L; RZPDo839A0262D protamine 1 (PRM1) gene, encodes complete protein.
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000312511.1, ENST00000312511.2, ENST00000312511.3, hCG_15067, NM_002761, P1, Q3MN80, Q3MN80_HUMAN, uc002dav.1, uc002dav.2, uc002dav.3, uc002dav.4, uc002dav.5 UCSC ID: ENST00000312511.4 RefSeq Accession: NM_002761
Protein: Q3MN80
CCDS: CCDS10547.1
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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