Human Gene NTAN1 (ENST00000287706.8) from GENCODE V44
Description: Homo sapiens N-terminal asparagine amidase (NTAN1), transcript variant 1, mRNA. (from RefSeq NM_173474) RefSeq Summary (NM_173474): The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000287706.8 Gencode Gene: ENSG00000157045.9 Transcript (Including UTRs) Position: hg38 chr16:15,037,857-15,056,074 Size: 18,218 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr16:15,038,031-15,055,971 Size: 17,941 Coding Exon Count: 10
ID:NTAN1_HUMAN DESCRIPTION: RecName: Full=Protein N-terminal asparagine amidohydrolase; EC=3.5.1.-; AltName: Full=Protein NH2-terminal asparagine amidohydrolase; Short=PNAA; AltName: Full=Protein NH2-terminal asparagine deamidase; Short=PNAD; Short=Protein N-terminal Asn amidase; Short=Protein NTN-amidase; FUNCTION: Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity). SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AB6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.