Human Gene KAT8 (uc002eax.3) Description and Page Index
Description: Homo sapiens K(lysine) acetyltransferase 8 (KAT8), transcript variant 2, mRNA. RefSeq Summary (NM_182958): This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr16:31,128,985-31,142,714 Size: 13,730 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr16:31,129,003-31,142,313 Size: 13,311 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF01853 - MOZ/SAS family PF11717 - RNA binding activity-knot of a chromodomain
ModBase Predicted Comparative 3D Structure on Q9H7Z6-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.