Human Gene KAT8 (uc002eax.3) Description and Page Index
  Description: Homo sapiens K(lysine) acetyltransferase 8 (KAT8), transcript variant 2, mRNA.
RefSeq Summary (NM_182958): This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Transcript (Including UTRs)
   Position: hg19 chr16:31,128,985-31,142,714 Size: 13,730 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr16:31,129,003-31,142,313 Size: 13,311 Coding Exon Count: 10 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:31,128,985-31,142,714)mRNA (may differ from genome)Protein (467 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.90 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 1023.76 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00180.000 Picture PostScript Text
3' UTR -158.20401-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01853 - MOZ/SAS family
PF11717 - RNA binding activity-knot of a chromodomain

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9H7Z6-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK225660 - Homo sapiens mRNA for Splice isoform 2 of Q9H7Z6 variant, clone: STM04995.
LQ871062 - Sequence 5 from Patent EP3369434.
LQ871063 - Sequence 6 from Patent EP3369434.
LX156537 - WO 2017073692-A/5: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LX156538 - WO 2017073692-A/6: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LF207925 - JP 2014500723-A/15428: Polycomb-Associated Non-Coding RNAs.
AK024102 - Homo sapiens cDNA FLJ14040 fis, clone HEMBA1005513, weakly similar to MALES-ABSENT ON THE FIRST PROTEIN (EC 2.3.1.-).
AK291106 - Homo sapiens cDNA FLJ78028 complete cds.
AK021872 - Homo sapiens cDNA FLJ11810 fis, clone HEMBA1006347, moderately similar to MALES-ABSENT ON THE FIRST PROTEIN (EC 2.3.1.-).
BC037773 - Homo sapiens MYST histone acetyltransferase 1, mRNA (cDNA clone MGC:41769 IMAGE:5278026), complete cds.
AB463911 - Synthetic construct DNA, clone: pF1KB7789, Homo sapiens MYST1 gene for MYST histone acetyltransferase 1, without stop codon, in Flexi system.
AF217501 - Homo sapiens histone acetyltransferase MYST1 (MYST1) mRNA, complete cds.
AF260665 - Homo sapiens histone acetyltransferase (MOF) mRNA, partial cds.
LQ871064 - Sequence 7 from Patent EP3369434.
LQ871065 - Sequence 8 from Patent EP3369434.
LQ871066 - Sequence 9 from Patent EP3369434.
LX156539 - WO 2017073692-A/7: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LX156540 - WO 2017073692-A/8: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LX156541 - WO 2017073692-A/9: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LQ871079 - Sequence 22 from Patent EP3369434.
LX156554 - WO 2017073692-A/22: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LF370040 - JP 2014500723-A/177543: Polycomb-Associated Non-Coding RNAs.
AF289578 - Homo sapiens clone pp7073 unknown mRNA.
LQ871081 - Sequence 24 from Patent EP3369434.
LX156556 - WO 2017073692-A/24: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LQ871080 - Sequence 23 from Patent EP3369434.
LX156555 - WO 2017073692-A/23: Inhibitor of methylation-related enzyme HAT1 and KAT8.
AL050395 - Homo sapiens mRNA; cDNA DKFZp586D1020 (from clone DKFZp586D1020).
LQ871082 - Sequence 25 from Patent EP3369434.
LX156557 - WO 2017073692-A/25: Inhibitor of methylation-related enzyme HAT1 and KAT8.
LF370044 - JP 2014500723-A/177547: Polycomb-Associated Non-Coding RNAs.
LF370045 - JP 2014500723-A/177548: Polycomb-Associated Non-Coding RNAs.
LF370046 - JP 2014500723-A/177549: Polycomb-Associated Non-Coding RNAs.
DQ581561 - Homo sapiens piRNA piR-49673, complete sequence.
JD042801 - Sequence 23825 from Patent EP1572962.
JD312309 - Sequence 293333 from Patent EP1572962.
JD400161 - Sequence 381185 from Patent EP1572962.
JD304006 - Sequence 285030 from Patent EP1572962.
MA605617 - JP 2018138019-A/177543: Polycomb-Associated Non-Coding RNAs.
MA605621 - JP 2018138019-A/177547: Polycomb-Associated Non-Coding RNAs.
MA605622 - JP 2018138019-A/177548: Polycomb-Associated Non-Coding RNAs.
MA605623 - JP 2018138019-A/177549: Polycomb-Associated Non-Coding RNAs.
MA443502 - JP 2018138019-A/15428: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H7Z6 (Reactome details) participates in the following event(s):

R-HSA-3321883 MSL acetylates histone H4
R-HSA-3321805 NSL acetylates histone H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: MOF, MYST1, NM_182958, NP_892003, PP7073, Q9H7Z6-2
UCSC ID: uc002eax.3
RefSeq Accession: NM_182958
Protein: Q9H7Z6-2 CCDS: CCDS45468.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_182958.2
exon count: 10CDS single in 3' UTR: no RNA size: 1840
ORF size: 1404CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 2759.00frame shift in genome: no % Coverage: 99.08
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.