Human Gene TANGO6 (ENST00000261778.2) from GENCODE V44
Description: Homo sapiens transport and golgi organization 6 homolog (TANGO6), mRNA. (from RefSeq NM_024562)
Gencode Transcript: ENST00000261778.2
Gencode Gene: ENSG00000103047.8
Transcript (Including UTRs)
Position: hg38 chr16:68,843,531-69,085,182 Size: 241,652 Total Exon Count: 18 Strand: +
Coding Region
Position: hg38 chr16:68,843,618-69,083,661 Size: 240,044 Coding Exon Count: 18
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TMCO7_HUMAN
DESCRIPTION: RecName: Full=Transmembrane and coiled-coil domain-containing protein 7;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).SIMILARITY: Belongs to the TMCO7 family.SIMILARITY: Contains 2 HEAT repeats.SEQUENCE CAUTION: Sequence=BAB14224.1; Type=Erroneous initiation; Sequence=BAB21837.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR019414 - DUF2411
Pfam Domains: PF10304 - Required for nuclear transport of RNA pol II C-terminus 2
ModBase Predicted Comparative 3D Structure on Q9C0B7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AB051533 - Homo sapiens KIAA1746 mRNA for KIAA1746 protein.LF384445 - JP 2014500723-A/191948: Polycomb-Associated Non-Coding RNAs.MA620022 - JP 2018138019-A/191948: Polycomb-Associated Non-Coding RNAs.AB463318 - Synthetic construct DNA, clone: pF1KA1746, Homo sapiens TMCO7 gene for transmembrane and coiled-coil domains containing protein 7, without stop codon, in Flexi system.AK095333 - Homo sapiens cDNA FLJ38014 fis, clone CTONG2012607.BC015617 - Homo sapiens hypothetical protein FLJ12688, mRNA (cDNA clone IMAGE:4841012), partial cds.AK022750 - Homo sapiens cDNA FLJ12688 fis, clone NT2RM4002534.KJ904869 - Synthetic construct Homo sapiens clone ccsbBroadEn_14263 TMCO7 gene, encodes complete protein.BC001813 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:2960034), containing frame-shift errors.BC001839 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:2960034), containing frame-shift errors.LF208300 - JP 2014500723-A/15803: Polycomb-Associated Non-Coding RNAs.MA443877 - JP 2018138019-A/15803: Polycomb-Associated Non-Coding RNAs.BC092500 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:5259359), with apparent retained intron.LF374298 - JP 2014500723-A/181801: Polycomb-Associated Non-Coding RNAs.MA609875 - JP 2018138019-A/181801: Polycomb-Associated Non-Coding RNAs.LF374299 - JP 2014500723-A/181802: Polycomb-Associated Non-Coding RNAs.MA609876 - JP 2018138019-A/181802: Polycomb-Associated Non-Coding RNAs.LF374301 - JP 2014500723-A/181804: Polycomb-Associated Non-Coding RNAs.MA609878 - JP 2018138019-A/181804: Polycomb-Associated Non-Coding RNAs.LF374304 - JP 2014500723-A/181807: Polycomb-Associated Non-Coding RNAs.MA609881 - JP 2018138019-A/181807: Polycomb-Associated Non-Coding RNAs.LF374311 - JP 2014500723-A/181814: Polycomb-Associated Non-Coding RNAs.MA609888 - JP 2018138019-A/181814: Polycomb-Associated Non-Coding RNAs.LF374340 - JP 2014500723-A/181843: Polycomb-Associated Non-Coding RNAs.MA609917 - JP 2018138019-A/181843: Polycomb-Associated Non-Coding RNAs.LF374341 - JP 2014500723-A/181844: Polycomb-Associated Non-Coding RNAs.MA609918 - JP 2018138019-A/181844: Polycomb-Associated Non-Coding RNAs.JD065761 - Sequence 46785 from Patent EP1572962.JD273914 - Sequence 254938 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000261778.1, KIAA1746, NM_024562, Q569F9, Q9C0B7, Q9H9K1, TMCO7, TMCO7_HUMAN, uc002ewi.1, uc002ewi.2, uc002ewi.3, uc002ewi.4, uc002ewi.5, uc002ewi.6UCSC ID: ENST00000261778.2RefSeq Accession: NM_024562
Protein: Q9C0B7
(aka TMCO7_HUMAN)
CCDS: CCDS45516.1
Methods, Credits, and Use Restrictions
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