Human Gene TANGO6 (ENST00000261778.2) from GENCODE V44
  Description: Homo sapiens transport and golgi organization 6 homolog (TANGO6), mRNA. (from RefSeq NM_024562)
Gencode Transcript: ENST00000261778.2
Gencode Gene: ENSG00000103047.8
Transcript (Including UTRs)
   Position: hg38 chr16:68,843,531-69,085,182 Size: 241,652 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr16:68,843,618-69,083,661 Size: 240,044 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:68,843,531-69,085,182)mRNA (may differ from genome)Protein (1094 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMCO7_HUMAN
DESCRIPTION: RecName: Full=Transmembrane and coiled-coil domain-containing protein 7;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMCO7 family.
SIMILARITY: Contains 2 HEAT repeats.
SEQUENCE CAUTION: Sequence=BAB14224.1; Type=Erroneous initiation; Sequence=BAB21837.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.21 RPKM in Testis
Total median expression: 130.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.1087-0.357 Picture PostScript Text
3' UTR -503.601521-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR019414 - DUF2411

Pfam Domains:
PF10304 - Required for nuclear transport of RNA pol II C-terminus 2

ModBase Predicted Comparative 3D Structure on Q9C0B7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Gene Details    Gene Details
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MGIRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB051533 - Homo sapiens KIAA1746 mRNA for KIAA1746 protein.
LF384445 - JP 2014500723-A/191948: Polycomb-Associated Non-Coding RNAs.
MA620022 - JP 2018138019-A/191948: Polycomb-Associated Non-Coding RNAs.
AB463318 - Synthetic construct DNA, clone: pF1KA1746, Homo sapiens TMCO7 gene for transmembrane and coiled-coil domains containing protein 7, without stop codon, in Flexi system.
AK095333 - Homo sapiens cDNA FLJ38014 fis, clone CTONG2012607.
BC015617 - Homo sapiens hypothetical protein FLJ12688, mRNA (cDNA clone IMAGE:4841012), partial cds.
AK022750 - Homo sapiens cDNA FLJ12688 fis, clone NT2RM4002534.
KJ904869 - Synthetic construct Homo sapiens clone ccsbBroadEn_14263 TMCO7 gene, encodes complete protein.
BC001813 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:2960034), containing frame-shift errors.
BC001839 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:2960034), containing frame-shift errors.
LF208300 - JP 2014500723-A/15803: Polycomb-Associated Non-Coding RNAs.
MA443877 - JP 2018138019-A/15803: Polycomb-Associated Non-Coding RNAs.
BC092500 - Homo sapiens transmembrane and coiled-coil domains 7, mRNA (cDNA clone IMAGE:5259359), with apparent retained intron.
LF374298 - JP 2014500723-A/181801: Polycomb-Associated Non-Coding RNAs.
MA609875 - JP 2018138019-A/181801: Polycomb-Associated Non-Coding RNAs.
LF374299 - JP 2014500723-A/181802: Polycomb-Associated Non-Coding RNAs.
MA609876 - JP 2018138019-A/181802: Polycomb-Associated Non-Coding RNAs.
LF374301 - JP 2014500723-A/181804: Polycomb-Associated Non-Coding RNAs.
MA609878 - JP 2018138019-A/181804: Polycomb-Associated Non-Coding RNAs.
LF374304 - JP 2014500723-A/181807: Polycomb-Associated Non-Coding RNAs.
MA609881 - JP 2018138019-A/181807: Polycomb-Associated Non-Coding RNAs.
LF374311 - JP 2014500723-A/181814: Polycomb-Associated Non-Coding RNAs.
MA609888 - JP 2018138019-A/181814: Polycomb-Associated Non-Coding RNAs.
LF374340 - JP 2014500723-A/181843: Polycomb-Associated Non-Coding RNAs.
MA609917 - JP 2018138019-A/181843: Polycomb-Associated Non-Coding RNAs.
LF374341 - JP 2014500723-A/181844: Polycomb-Associated Non-Coding RNAs.
MA609918 - JP 2018138019-A/181844: Polycomb-Associated Non-Coding RNAs.
JD065761 - Sequence 46785 from Patent EP1572962.
JD273914 - Sequence 254938 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261778.1, KIAA1746, NM_024562, Q569F9, Q9C0B7, Q9H9K1, TMCO7, TMCO7_HUMAN, uc002ewi.1, uc002ewi.2, uc002ewi.3, uc002ewi.4, uc002ewi.5, uc002ewi.6
UCSC ID: ENST00000261778.2
RefSeq Accession: NM_024562
Protein: Q9C0B7 (aka TMCO7_HUMAN)
CCDS: CCDS45516.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.