Human Gene CMTR2 (ENST00000434935.7) from GENCODE V44
Description: Homo sapiens cap methyltransferase 2 (CMTR2), transcript variant 1, mRNA. (from RefSeq NM_018348)
Gencode Transcript: ENST00000434935.7
Gencode Gene: ENSG00000180917.18
Transcript (Including UTRs)
Position: hg38 chr16:71,281,392-71,289,402 Size: 8,011 Total Exon Count: 3 Strand: -
Coding Region
Position: hg38 chr16:71,283,608-71,285,920 Size: 2,313 Coding Exon Count: 1
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FTSJ1_HUMAN
DESCRIPTION: RecName: Full=FtsJ methyltransferase domain-containing protein 1; EC=2.1.1.-; AltName: Full=Protein adrift homolog;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).SIMILARITY: Belongs to the methyltransferase superfamily. RlmE family. Adrift subfamily.SEQUENCE CAUTION: Sequence=AAM49718.1; Type=Frameshift; Positions=337; Sequence=BAA91058.1; Type=Frameshift; Positions=739; Sequence=BAB14452.1; Type=Erroneous initiation;
Primer design for this transcript
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR025807 - Adrift_MeTrfase
IPR002877 - rRNA_MeTrfase_FtsJ_dom
Pfam Domains: PF01728 - FtsJ-like methyltransferase
ModBase Predicted Comparative 3D Structure on Q8IYT2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX648660 - Homo sapiens mRNA; cDNA DKFZp686P1938 (from clone DKFZp686P1938).AK023183 - Homo sapiens cDNA FLJ13121 fis, clone NT2RP3002687.BC035005 - Homo sapiens FtsJ methyltransferase domain containing 1, mRNA (cDNA clone MGC:33269 IMAGE:5267637), complete cds.AK000289 - Homo sapiens cDNA FLJ20282 fis, clone HEP03828.BC034468 - Homo sapiens FtsJ methyltransferase domain containing 1, mRNA (cDNA clone MGC:26159 IMAGE:4824516), complete cds.JD314139 - Sequence 295163 from Patent EP1572962.JD508258 - Sequence 489282 from Patent EP1572962.AK002033 - Homo sapiens cDNA FLJ11171 fis, clone PLACE1007317, weakly similar to Drosophila melanogaster Adrift mRNA.JD226325 - Sequence 207349 from Patent EP1572962.JD155180 - Sequence 136204 from Patent EP1572962.AK226169 - Homo sapiens mRNA for hypothetical protein LOC55783 variant, clone: ej01021.AK315056 - Homo sapiens cDNA, FLJ96008.JF432273 - Synthetic construct Homo sapiens clone IMAGE:100073445 FtsJ methyltransferase domain containing 1 (FLJ11171) gene, encodes complete protein.KJ899192 - Synthetic construct Homo sapiens clone ccsbBroadEn_08586 FTSJD1 gene, encodes complete protein.AB385037 - Synthetic construct DNA, clone: pF1KB5099, Homo sapiens FLJ11171 gene for FLJ11171 protein, complete cds, without stop codon, in Flexi system.AF458590 - Homo sapiens hypothetical protein mRNA, complete cds.CU690018 - Synthetic construct Homo sapiens gateway clone IMAGE:100020069 5' read FLJ11171 mRNA.AK123343 - Homo sapiens cDNA FLJ41349 fis, clone BRAWH2012077.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7379 - mRNA capping II
Other Names for This Gene
Alternate Gene Symbols: AFT, B2RCD5, D3DWS1, ENST00000434935.1, ENST00000434935.2, ENST00000434935.3, ENST00000434935.4, ENST00000434935.5, ENST00000434935.6, FTSJ1_HUMAN, FTSJD1, NM_018348, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5, uc002ezy.1, uc002ezy.2, uc002ezy.3, uc002ezy.4, uc002ezy.5, uc002ezy.6UCSC ID: ENST00000434935.7RefSeq Accession: NM_018348
Protein: Q8IYT2
(aka FTSJ1_HUMAN)
CCDS: CCDS10898.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.