Human Gene MLKL (ENST00000306247.11) from GENCODE V44
Description: Homo sapiens mixed lineage kinase domain like pseudokinase (MLKL), transcript variant 2, mRNA. (from RefSeq NM_001142497) RefSeq Summary (NM_001142497): This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENST00000306247.11 Gencode Gene: ENSG00000168404.13 Transcript (Including UTRs) Position: hg38 chr16:74,671,855-74,700,790 Size: 28,936 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr16:74,672,504-74,695,757 Size: 23,254 Coding Exon Count: 5
ID:MLKL_HUMAN DESCRIPTION: RecName: Full=Mixed lineage kinase domain-like protein; INTERACTION: Q9Y572:RIPK3; NbExp=10; IntAct=EBI-1055040, EBI-298250; DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NB16
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007166 cell surface receptor signaling pathway GO:0012501 programmed cell death GO:0035556 intracellular signal transduction GO:0070207 protein homotrimerization GO:0070266 necroptotic process GO:0006468 protein phosphorylation
US Server
